Results 61 to 70 of about 417,988 (310)

Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn’s disease

BMC Gastroenterology, 2022
Backgrounds Optimal concentration of ustekinumab (UST) predicting endoscopic remission has not been fully investigated in Crohn’s disease (CD). We aimed to identify the optimal UST trough levels predicting clinical, laboratory and endoscopic remission in
Hisashi Hirayama, Yasuhiro Morita, Takayuki Imai, Kenichiro Takahashi, Atsushi Yoshida, Shigeki Bamba, Osamu Inatomi, Akira Andoh   +7 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

The importance of TNF-α signaling: a potential risk factor in neurodegenerative and cardiovascular diseases

Archives of Medical Science
Cytokines are small, membrane-bound, protein-based cell signaling molecules that aid cell-to-cell communication in physiological and pathological processes. TNF-α is a pleiotropic cytokine that is regarded as a principal cytokine in the acute and chronic
Marta Białecka, Monika Białecka, Anna Machoy-Mokrzyńska, Damian Malinowski, Monika Rać   +4 more
doaj   +1 more source

Therapeutic Drug Monitoring of Long-Acting Injectable Antipsychotic Drugs

, 2021
BACKGROUND The use of therapeutic drug monitoring (TDM) to guide treatment with long-acting injectable (LAI) antipsychotics, which are increasingly prescribed, remains a matter of debate. The aim of this review was to provide a practical framework for
Mössner, R., Havemann-Reinecke, Ursula, Baumann, Pierre, Kuzin, Maxim, Piacentino, Daria, Steimer, W., Christoph Hiemke, Gründer, Gerhard, Havemann-Reinecke, U., Daria Piacentino, Gründer, G., Hefner, G., Gerald Zernig, Zernig, G., Giancarlo Giupponi, Conca, A., Conca, Andreas, Martina Hahn, Baumann, P., Steimer, Werner, Maxim Kuzin, Schoretsanitis, Georgios, Xenia Hart, Andreas Conca, Ursula Havemann-Reinecke, Giupponi, Giancarlo, Gudrun Hefner, Hiemke, Christoph, Gerhard Gründer, Zernig, Gerald, Dietmaier, O., Giupponi, G., Otto Dietmaier, Rainald Mössner, Werner Steimer, Hefner, Gudrun, Dietmaier, Otto, Piacentino, D., Hiemke, C., Schoretsanitis, G., Hart, X., Hart, Xenia, Kuzin, M., Georgios Schoretsanitis, Pierre Baumann, Mössner, Rainald, Hahn, Martina, Hahn, M.   +47 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Therapeutic Drug Monitoring in Inflammatory Bowel Disease

Journal of Coloproctology, 2023
Inflammatory bowel disease (IBD) is a problem that directly affects the quality of life of patients suffering from this condition. Monitoring the serum level of infliximab (IFX) (TDM) is an important tool for guiding therapeutic decisions in IBD patients.
Manoel Alvaro de Freitas Lins Neto, João Otávio Moraes Rolim, Diogo César Maurício de Oliveira Jatobá, Júnia Elisa Carvalho de Meira, Luís Henrique Salvador Filho, Lucas Correia Lins, Jorge Artur Coelho Peçanha   +6 more
doaj   +1 more source

Therapeutic drug monitoring data on olanzapine and its N-demethyl metabolite in the naturalistic clinical setting

, 2002
Olanzapine (Zyprexa«) was approved for general prescription in Sweden in November 1996, and an HPLC-based therapeutic drug monitoring (TDM) routine for serum olanzapine (OLA) and its major metabolite, N-demethylolanzapine (DMO) was established in ...
Reis, Margareta,, Skogh, Elisabeth,, Dahl, Marja-Liisa, Bengtsson, Finn,, Lundmark, Jöns,   +4 more
core   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Therapeutic drug monitoring of immunosuppressant drugs in Marmara University Hospital

, 2004
Immunosuppressive therapy is the most crucial treatment of organ-transplanted patients. Both cyclosporin and tacrolimus have become a part of the standard immunosuppressive therapy for prevention of rejection.
AKICI, AHMET, YANANLI, HASAN RACİ, KARAALP, ATİLA, ONAT, FİLİZ   +3 more
core   +1 more source

Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs

, 2020
BACKGROUND: For oral anticancer drugs, trough concentration (Cmin) is usually used as a target in therapeutic drug monitoring (TDM). Recording of Cmin is highly challenging in outpatients, in whom there is typically a variability in sample collection ...
Huitema, Alwin D R, Alwin D.R. Huitema, Julie M. Janssen, Dorlo, Thomas P C,, Janssen, Julie M, Thomas P.C. Dorlo, Jos H. Beijnen, Beijnen, Jos H   +7 more
core   +1 more source