Results 31 to 40 of about 405,448 (165)
Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs
Frontiers in Veterinary ScienceIntroductionPhenobarbital (PB) remains the first-line treatment for canine epilepsy due to its efficacy, affordability, and favorable pharmacokinetics.
Silvana Alvariza +6 more
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Gülhane Tıp Dergisi, 2022 Aims:Gentamicin is routinely used in neonates as an empirical antibiotic for suspected sepsis at a dose of 4.0 mg/kg, either 24 or 36 hourly based on premenstrual age. Regularly, therapeutic drug monitoring is performed.
Suzana Mustafa +3 more
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European Psychiatry, 2021 Pregnancy is associated with profound changes in pharmacokinetic processes. This is an important - and until recently neglected - area of research since the majority of women take drugs during pregnancy in addition to vitamin and dietary supplements ...
A. Wieck
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Therapeutic drug monitoring of cytotoxic drugs [PDF]
British Journal of Clinical Pharmacology, 2001 Therapeutic drug monitoring is not routinely used for cytotoxic agents. There are several reasons, but one major drawback is the lack of established therapeutic concentration ranges. Combination chemotherapy makes the establishment of therapeutic ranges for individual drugs difficult, the concentration‐effect relationship for a single drug may not be ...
openaire +3 more sources
Therapeutic Drug Monitoring in Inflammatory Bowel Disease
Journal of Coloproctology, 2023 Inflammatory bowel disease (IBD) is a problem that directly affects the quality of life of patients suffering from this condition. Monitoring the serum level of infliximab (IFX) (TDM) is an important tool for guiding therapeutic decisions in IBD patients.
Manoel Alvaro de Freitas Lins Neto +6 more
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Archives of Medical ScienceCytokines are small, membrane-bound, protein-based cell signaling molecules that aid cell-to-cell communication in physiological and pathological processes. TNF-α is a pleiotropic cytokine that is regarded as a principal cytokine in the acute and chronic
Marta Białecka +4 more
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BMC Gastroenterology, 2022 Backgrounds Optimal concentration of ustekinumab (UST) predicting endoscopic remission has not been fully investigated in Crohn’s disease (CD). We aimed to identify the optimal UST trough levels predicting clinical, laboratory and endoscopic remission in
Hisashi Hirayama +7 more
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PharmaceuticalsBackground: Diclofenac is a phenylacetic acid derivative classified as a non-selective COX inhibitor. Similar to other NSAIDs, it is characterized by anti-inflammatory, antipyretic, and analgesic effects. Long-term therapy with diclofenac might also lead
Urszula Adamiak-Giera +11 more
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Formulation Approaches for Optimizing Omeprazole Stability in Oral Liquid Dosage Forms
PharmaceuticsBackground/Objectives: This study aimed to evaluate the degradation of omeprazole suspension under various pH conditions and to propose recommendations for preparing compounded suspensions.
Urszula Adamiak-Giera +6 more
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Optical Biosensors for Therapeutic Drug Monitoring
Biosensors, 2019 Therapeutic drug monitoring (TDM) is a fundamental tool when administering drugs that have a limited dosage or high toxicity, which could endanger the lives of patients.
Vivian Garzón +4 more
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