Results 21 to 30 of about 405,448 (165)

Rosemary and CoQ10 Alleviated the Detrimental Effects of Concomitant Administration of Acetaminophen and Carbamazepine by Accelerating Their Metabolism and Elimination

Indonesian Biomedical Journal, 2022
BACKGROUND: The interaction of carbamazepine (CBZ) and acetaminophen (APAP) could result in hepatic failure and mortality. This study was conducted to analyzed the potential of rosemary ethanol extract (REE) or coenzyme Q10 (CoQ10) to alleviate the ...
Marwa Magdy Hamido, Nashwah Ismail Zaki, Sawsan Ahmed Nasr, Wael Mohamed El-Sayed   +3 more
doaj   +1 more source

TGF-β1 and TGFβR2 Gene Polymorphisms in Patients with Unstable Angina

Biomedicines, 2023
Acute coronary syndromes result from a sudden reduction in the lumen of a coronary artery as a result of atherosclerotic plaque rupture, its swelling or the formation of thrombotic lesions.
Damian Malinowski, Krzysztof Safranow, Andrzej Pawlik   +2 more
doaj   +1 more source

Comparation of time-course, dose-effect, influencing factors and adverse events of biologics in the treatment of adults with moderate to severe plaque psoriasis

Frontiers in Immunology, 2023
IntroductionBiologics is used for treating moderate to severe plaque psoriasis (MSPP), which represent one of the foremost therapeutic advancements in disease of dermatology.
Weiqi Gao, Weiqi Gao, Weiqi Gao, Boran Yu, Ya Yan, Libo Zhao, Libo Zhao, Libo Zhao, Rongsheng Zhao, Rongsheng Zhao, Rongsheng Zhao   +10 more
doaj   +1 more source

Therapeutic drug monitoring of immunosuppressant drugs [PDF]

British Journal of Clinical Pharmacology, 1999
Individualizing a patient’s drug therapy to obtain the optimum balance between therapeutic efficacy and the occurrence of adverse events is the physician’s goal. However, achieving this goal is not always straight forward, being complicated by within and between patient variability in both pharmacokinetics and pharmacodynamics.
A, Johnston, D W, Holt
openaire   +2 more sources

Therapeutic drug monitoring: antiarrhythmic drugs [PDF]

British Journal of Clinical Pharmacology, 1998
Antiarrhythmic agents are traditionally classified according to Vaughan Williams into four classes of action. Class I antiarrhythmic agents include most of the drugs traditionally thought of as antiarrhythmics, and have as a common action, blockade of the fast‐inward sodium channel on myocardium. These agents have a very significant toxicity, and while
T J, Campbell, K M, Williams
openaire   +4 more sources

Two cases of a pharmacokinetic interaction between (val)acyclovir and mycophenolate mofetil

Clinical Infection in Practice, 2023
Background: Administration of (val)acyclovir in combination with mycophenolate mofetil (MMF) can result in increased acyclovir plasma levels due to competition with acyclovir for renal tubular secretion.
F.A. Berger, J.E. Nagtegaal, M.M. Malingré   +2 more
doaj   +1 more source

Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients

Journal of Intensive Care, 2018
Background Analgosedation is a cornerstone therapy for mechanically ventilated patients in intensive care units (ICU). To avoid inadequate sedation and its complications, monitoring of analgosedation is of great importance.
Richard J. Nies, Carsten Müller, Roman Pfister, Philipp S. Binder, Nicole Nosseir, Felix S. Nettersheim, Kathrin Kuhr, Martin H. J. Wiesen, Matthias Kochanek, Guido Michels   +9 more
doaj   +1 more source

Therapeutic Drug Monitoring of Voriconazole [PDF]

Therapeutic Drug Monitoring, 2008
Voriconazole is a triazole antifungal developed for the treatment of life-threatening fungal infections in immunocompromised patients. The drug, which is available for both oral and intravenous administration, has broad-spectrum activity against pathogenic yeasts, dimorphic fungi, and opportunistic molds.
Bruggemann, R.J.M., Donnelly, J.P., Aarnoutse, R.E., Warris, A., Blijlevens, N.M.A., Mouton, J.W., Verweij, P.E., Burger, D.M.   +7 more
openaire   +3 more sources

Therapeutic Drug Monitoring of Antibiotics Is Needed in the Treatment of Sepsis

Вестник анестезиологии и реаниматологии, 2022
The article presents the results of a prospective one-center observational clinical study.The level of therapeutic drug monitoring antibiotics was studied in patients with sepsis.The objective: to assess the impact of pharmacokinetics and ...
G. P. Plotnikov, A. N. Kudryavtsev, A. A. Kleuzovich, A. G. Chizhov, A. A. Ponomarev, S. S. Larin, E. A. Litvin, L. A. Anastasevich   +7 more
doaj   +1 more source

Therapeutic Drug Monitoring of Antibody Drugs

Biological and Pharmaceutical Bulletin, 2022
In recent years, many antibody drugs that play an important role in the pharmacotherapy of several diseases have been developed. Antibody drugs exhibit immunogenicity in vivo leading to the development of antibodies against the antibody drug (anti-drug antibody). Nonetheless, other factors also affect the pharmacokinetics of antibody drugs.
openaire   +2 more sources