Results 11 to 20 of about 28,368 (156)

WHAT IS THERAPEUTIC EQUIVALENCE OF GENERIC DRUG AND HOW TO PROVE IT

Рациональная фармакотерапия в кардиологии, 2016
The problem of generic drugs use in clinical practice and confirmation of their therapeutic equivalence is discussed. The significance of studies on generic drugs bioequivalence, as well as details of international practice and regulations in this area ...
N. P. Kutishenko, S. Yu. Martsevich, I. V. Vashurina   +2 more
doaj   +1 more source

VALUE OF THERAPEUTIC EQUIVALENCE IN SUBSTITUTION OF ORIGINAL DRUG WITH GENERIC BY EXAMPLE OF FOSINIPRIL

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study the therapeutic equivalence of original and generic fosinopril in patients with arterial hypertension (HT) of 1-2 degrees, and to evaluate the cost effectiveness of original drug substitution with generic. Material and methods.
N. P. Kutishenko, S. Yu. Martsevich, Zh. D. Kobalava, E. K. Shavarova   +3 more
doaj   +1 more source

ДЖЕНЕРИЧЕСКИЕ СТАТИНЫ В КЛИНИЧЕСКОЙ ПРАКТИКЕ: ДЕШЕВЫЕ ЗАМЕНИТЕЛИ ИЛИ ДОСТОЙНАЯ АЛЬТЕРНАТИВА БРЕНДАМ. АТОРВАСТАТИН

Архивъ внутренней медицины, 2012
The relevance of cardiovascular disease in the world and in Russia causes including calls for patient compliance with medical recommendations. Compliance, in turn, depends on the cost of medicines. From an economic point of view generic drugs appear in a
В. П. Михин, Ю. А. Жиляева   +1 more
doaj   +1 more source

PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGES

Рациональная фармакотерапия в кардиологии, 2016
The main differences between original and generic drugs as well as registration criteria for generics are described. Possible reasons of discrepancy in bioequivalence and therapeutic equivalence of original and generic drugs are reviewed. The examples of
S. N. Tolpygina, S. Yu. Martsevich
doaj   +3 more sources

New Anticonvulsants: Interchangeability Issues and the Use of Generic Anticonvulsants in Clinical Practice

Регуляторные исследования и экспертиза лекарственных средств, 2019
This article looks into interchangeability and therapeutic equivalence of innovator and generic anticonvulsants — the first-generation and new antiepileptic drugs (AEDs).
V. V. Arkhipov, E. A. Sokova, G. I. Gorodetskaya, O. A. Demidova, T. V. Aleksandrova   +4 more
doaj   +1 more source

Current Approaches to Demonstration of Therapeutic Equivalence of Locally-Acting Gastrointestinal Drugs

Регуляторные исследования и экспертиза лекарственных средств, 2021
Evolution of knowledge about pharmacokinetics and pharmacodynamics of locally acting products, and an increase in the number of generics and medicines under development have laid the ground for the development of new scientific approaches to planning and
E. V. Gorbunova, D. V. Goryachev, T. E. Gorskaya, A. N. Bogdanov   +3 more
doaj   +1 more source

PREDICTION OF THE INFLUENCE OF ORIGINAL AND GENERIC ROSUVASTATIN ON DIRECT MEDICAL COSTS OF SECONDARY PREVENTION IN PATIENTS WITH CHRONIC TYPES OF ISCHEMIC HEART DISEASE

Кардиоваскулярная терапия и профилактика, 2015
Aim. To study therapeutic equivalence of rosuvastatin generic and original medication and to conduct the pharmacoeconomic analysis to compare the impact of the drug on direct expenses in secondary prevention for the patients with chronic ischemic heart ...
E. I. Tarlovskaya, G. I. Nechaeva, S. V. Malchikova, А. А. Semenkin   +3 more
doaj   +1 more source

Efficacy and safety of a switch from twice-daily tacrolimus to once-daily generic tacrolimus in stable liver transplant patients

Korean Journal of Transplantation, 2021
Background : Once-daily tacrolimus reduces non-compliance relative to twice-daily tacrolimus. However, little is known about the safety and efficacy of conversion from twice-daily tacrolimus to generic once-daily tacrolimus in liver transplantation (LT).
Jong Man Kim, Pyoung-Jae Park, Geun Hong, Dong Jin Joo, Kwan Woo Kim, Je Ho Ryu, Young Seok Han, Jai Young Cho, Gi-Won Song, Bong-Wan Kim, Dong-Sik Kim, Seong Hoon Kim, Sang Tae Choi, Young Kyoung You, Kyung-Suk Suh, Yang-Won Na, Koo Jeong Kang, Jae-Won Joh   +17 more
doaj   +1 more source

Safety of Use of Russian Biosimilars of Interferon Beta-1b in the Treatment of Multiple Sclerosis: a Meta-analysis of Original Studies

Безопасность и риск фармакотерапии, 2019
Presently, an active search for  modern drugs for  the  treatment of multiple sclerosis is ongoing. Since  the  treatment with original drugs is expensive, therefore, the  development of local biosimilars is underway, which at a lower  cost should be ...
D. O. Gudz, A. E. Krasnov, R. N. Mamleev, R. K. Kagirov, M. L. Maximov   +4 more
doaj   +1 more source

A COMPARATIVE STUDY OF THE EFFICACY AND TOLERABILITY OF ORIGINAL AND GENERIC BISOPROLOL IN MONOTHERAPY OR IN COMBINATION WITH S-AMLODIPINE AND INDAPAMIDE IN PATIENTS WITH ARTERIAL HYPERTENSION 1-2 DEGREES. RESULTS OF THE CLINICAL RANDOMIZED CROSSOVER STUDY

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study the clinical equivalence of original and generic drugs of bisoprolol in patients with arterial hypertension (HT) 1-2 degrees according to protocol recommended by the Society of Cardiology of the Russian Federation for comparative studies ...
S. Yu. Martsevich, S. N. Tolpygina, V. P. Voronina, O. V. Lerman, Yu. V. Lukina, N. A. Dmitrieva, I. V. Vashurina   +6 more
doaj   +1 more source