Results 151 to 160 of about 2,567,854 (328)

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Methylxanthine use in infants with hypoxic-ischemic encephalopathy: a retrospective cohort study

Scientific Reports
Therapeutic hypothermia is the standard treatment for hypoxic-ischemic encephalopathy (HIE), but despite its widespread use, the rates of mortality and neurodevelopmental impairment for moderate to severe HIE remain around 30%.
Madeleine E. Laughon, Jacob K. Johnson, Rachel G. Greenberg, Reese H. Clark, Wesley M. Jackson   +4 more
doaj   +1 more source

Oklahoma Heart Hospital: Clinician Leaders Establish Culture of Quality [PDF]

, 2009
Describes strategies for a culture of quality, including a flat organizational structure, optimal nurse experience and ratios, standardization through care sets, technology-enabled feedback and assessment, and continuous improvement through new ...
Sharon Silow-Carroll
core  

Differences in prediction of adverse perinatal outcome in term pregnancies by choice of fetal growth reference: A validation study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In this study of 1 126 059 pregnancies, we find evidence of comparable predictive ability for adverse perinatal outcomes across four fetal growth references, but with notable differences in sensitivity and false positive rate (FPR). The WHO reference demonstrated balanced performance in detecting at‐risk fetuses, suggesting its suitability for clinical
Linda Lindström, Fredrik Ahlsson, Ove Axelsson, Michaela Granfors, Erik Lampa, Maria Nelander, Anna‐Karin Wikström   +6 more
wiley   +1 more source

Enteral nutritional strategy during therapeutic hypothermia: who? when? what?

Frontiers in Pediatrics
BackgroundThere are no guidelines regarding enteral feeding (EF) of infants with hypoxic-ischemic encephalopathy (HIE) during and shortly after therapeutic hypothermia; consequently, clinical practice is, to date, still variable.
Simonetta Costa, Irene Del Rizzo, Simona Fattore, Francesca Serrao, Francesca Priolo, Mirta Corsello, Eloisa Tiberi, Milena Tana, Paola Catalano, Giovanni Vento   +9 more
doaj   +1 more source

Hypothermia for perinatal asphyxial encephalopathy. A Swiss survey of opinion, practice and cerebral investigations [PDF]

, 2011
BACKGROUND: Perinatal asphyxial encephalopathy occurs in 1-per 1000 live births and is associated with high mortality and morbidity. Therapeutic hypothermia increases intact survival and improves neurodevelopmental outcome in survivors.AIMS: To evaluate (
Berger, TM, Bernet, V, Brotschi, B, Hagmann, CF, Latal, B, Robertson, NJ   +5 more
core  

Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion

Artificial Organs, EarlyView.
This study aimed to investigate the influence of warm ischemic injury on renal vascular responsiveness to vasoactive drugs during normothermic machine perfusion (NMP). We found that the vascular responses to dopamine and norepinephrine could be used as objective indicators to assess kidney viability during NMP.
Isa M. van Tricht, Baran Ogurlu, Silke S. M. Wolfswinkel, Henri G. D. Leuvenink, Cyril Moers   +4 more
wiley   +1 more source

Optimizing Prolonged (6 h) Normothermic Machine Perfusion of Donor Kidneys (PROPER Study)

Artificial Organs, EarlyView.
Prolonged ex situ normothermic machine perfusion of donor kidneys up to 6 h is feasible, maintaining viability and histological integrity. Key protocol optimizations include fresh red blood cells, albumin supplementation, and urine recirculation—laying the groundwork for assessment and potential pretransplant interventions in future clinical trials ...
Asel S. Arykbaeva, Veerle A. Lantinga, L. Leonie van Leeuwen, Marten Engelse, Ton J. Rabelink, Jesper Kers, Jason B. Doppenberg, Volkert A. L. Huurman, Robert A. Pol, Robert C. Minnee, Henri G. D. Leuvenink, Rutger J. Ploeg, Cyril Moers, Dorottya K. de Vries, Ian P. J. Alwayn   +14 more
wiley   +1 more source

Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini‐Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim Medical gases, including nitric oxide, carbon monoxide, hydrogen sulphide and molecular hydrogen, have emerged as key regulators of redox balance and cellular signalling. This mini‐review examines their relevance to paediatric endocrine and neurodevelopmental pathways, domains particularly sensitive to oxidative and inflammatory ...
Roberto Paparella, Fabiola Panvino, Ida Pucarelli, Luigi Tarani   +3 more
wiley   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source