Results 1 to 10 of about 1,892,351 (211)

Hereditary hemochromatosis: pathogenesis, symptoms, diagnosis and current treatment - literature review

Journal of Education, Health and Sport
Introduction: Hereditary hemochromatosis is the most common genetic disorder in Northern Europe. It involves an overload of iron in the tissues due to a deficiency of the protein hepcidin.
Dominika Prystacka-Szar, Natalia Rulewska, Filip Grabowski, Jakub Siemko, Dagmara Neska , Justyna Stadler-Szajda, Adrianna Czyżnikiewicz, Wenancjusz Stołowski, Magdalena Bujak, Magdalena Waśniowska   +9 more
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Therapeutic Depletion of Iron Stores Is Not Associated with a Reduced Hemoglobin Mass in a Hemochromatosis Patient

Case Reports in Gastroenterology, 2016
Introduction: Hereditary hemochromatosis features a dysregulated iron absorption leading to iron overload and organ damage. The regulation of total hemoglobin mass during depletion of iron deposits by therapeutic phlebotomy has not been studied.
Nina Wrobel, Torben Pottgiesser, Philipp Birkner, Peter Deibert, Christoph Ahlgrim   +4 more
doaj   +1 more source

Novel therapeutics in myeloproliferative neoplasms

Journal of Hematology & Oncology, 2020
Hyperactive signaling of the Janus-Associated Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) pathway is central to the pathogenesis of Philadelphia-chromosome-negative myeloproliferative neoplasms (MPN), i.e., polycythemia vera (PV),
Sangeetha Venugopal, John Mascarenhas
doaj   +1 more source

Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis

Scientific Reports, 2019
Development of advanced hepatic fibrosis in HFE Hemochromatosis (HH) is influenced by hepatic iron concentration (HIC) and age. In patients with HH, it is important to assess the likelihood of cirrhosis and thus the need for confirmatory liver biopsy ...
Justin Chin, Lawrie W. Powell, Louise E. Ramm, Oyekoya T. Ayonrinde, Grant A. Ramm, John K. Olynyk   +5 more
doaj   +1 more source

Hereditary Hemochromatosis: Pathophysiological Basis and Emerging Therapeutic Approaches—A Systematic Review of Clinical Evidence

Future Pharmacology
Introduction: Hereditary hemochromatosis is a genetic disorder characterized by dysregulation of iron homeostasis, resulting in excessive intestinal iron absorption and progressive iron deposition in vital organs.
Victor Cardoso Jacinto da Silva, Janaina Pereira Dina Toreli, Edimar Cristiano Pereira, Araceli Aparecida Hastreiter, Beatriz Alves, Thais Gascon, Glaucia Raquel Luciano da Veiga, Samantha Sanchez de Carvalho, Fernando Luiz Affonso Fonseca   +8 more
doaj   +1 more source

RECRUITMENT OF PATIENTS WITH HEREDITARY HAEMOCHROMATOSIS AS BLOOD DONORS

Zdravniški Vestnik, 2004
Background. Hereditary haemochromatosis is the most common inherited disorder in white persons with prevalence of about 1 in 200. Therapeutic phlebotomy is an effective treatment for the disease and prevents its sequele.
Marko Cukjati, Dragoslav Domanovič
doaj  

Secondary Polycythemia in A Young Male Patient with Nephrotic Syndrome

Jurnal Penyakit Dalam Indonesia
Polycythemia is a condition characterized by an abnormal increase in the total red blood cell mass and is classified into primary and secondary polycythemia.
Ariani Intan Wardhani, Pringgodigdo Nugroho, Ikhwan Rinaldi, Meilania Sarasawati, Monik Ediana Miranda, Agnes Stephanie Harahap   +5 more
doaj   +1 more source

RECENT INSIGHTS INTO SECONDARY ERYTHROCYTOSIS: PART II. MANAGEMENT APPROACHES

Клінічна та профілактична медицина
Introduction. The etiological heterogeneity of secondary erythrocytosis (SE), together with the coexistence of several potential contributing factors in a single patient, complicates the standardization of therapeutic strategies and warrants an ...
Mariia A. Trypilka, Oksana M. Kostiukevych, Lesia K. Benkovska   +2 more
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Hemodynamic Changes in Blood Donors

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2004
Introduction: Everyday, millions of people around the world go through phlebotomy, either to donate blood or for therapeutic intention. The most important worrisome adverse effects are hemodynamic alterations. In this study, hemodynamic changes following
M Rafiei, M Moddares-Mosadegh, M Emami- Maibodi, M Sadr-Bafghi, MH Ahmadieh   +4 more
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The oral ferroportin inhibitor vamifeport prevents liver iron overload in a mouse model of hemochromatosis

HemaSphere
Hemochromatosis is an inherited iron overload condition caused by mutations that reduce the levels of the iron‐regulatory hormone hepcidin or its binding to ferroportin.
Naja Nyffenegger, Anna Flace, Ahmet Varol, Patrick Altermatt, Cédric Doucerain, Hanna Sundstrom, Franz Dürrenberger, Vania Manolova   +7 more
doaj   +1 more source