Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet [PDF]
, 2016 Heterozygous mutations of the Hfe gene have been proposed as cofactors in the development and progression of nonalcoholic fatty liver disease (NAFLD). Homozygous Hfe deletion previously has been shown to lead to dysregulated hepatic lipid metabolism and ...
Bridle, Kim +7 more
core +2 more sources
Safety and tolerability of amustaline/glutathione pathogen‐reduced red blood cells in neonatal rats
Transfusion, EarlyView.Abstract Background Amustaline (S‐303)/glutathione (GSH) pathogen‐reduced red blood cells (PR‐RBCs) are in development for all adult and pediatric RBC transfusion indications, including neonates and infants. A neonatal rat model evaluated the safety and tolerability of PR‐RBCs during growth and maturation. Study Design and Methods Repeated transfusions
Anne North +3 more
wiley +1 more source
Persistent Erythrocytosis in a Dog With a Spinal Sclerosing Paraganglioma
Veterinary Clinical Pathology, EarlyView.ABSTRACT A 7‐year‐old, male, castrated, mixed‐breed dog presented with right pelvic limb lameness and pain on posturing to defecate that began 1.5 years prior to presentation. Radiographs taken 8 months prior to presentation showed a small lytic lesion of the L6 vertebral body, and CBCs showed a persistently increased hematocrit (HCT) for at least 2 ...
Samuel V. Neal +11 more
wiley +1 more source
RECRUITMENT OF PATIENTS WITH HEREDITARY HAEMOCHROMATOSIS AS BLOOD DONORS
Zdravniški Vestnik, 2004 Background. Hereditary haemochromatosis is the most common inherited disorder in white persons with prevalence of about 1 in 200. Therapeutic phlebotomy is an effective treatment for the disease and prevents its sequele.
Marko Cukjati, Dragoslav Domanovič
doaj
Cost-effectiveness of HCV case-finding for people who inject drugs via dried blood spot testing in specialist addiction services and prisons [PDF]
, 2013 ObjectivesPeople who inject drugs (PWID) are at high risk for acquiring hepatitis C virus (HCV), but many are unaware of their infection. HCV dried blood spot (DBS) testing increases case-finding in addiction services and prisons.
Hickman, Matthew +5 more
core +2 more sources
Vox Sanguinis, EarlyView.Abstract Background and Objectives While deferral due to low haemoglobin (Hb) is known to affect donor return, how donors react to and manage low Hb is less well understood. This paper aims to (1) describe donor activities to manage low Hb, and (2) examine donor knowledge, recalled emotions, satisfaction and potential concerns, and to determine their ...
Amanda Thijsen +3 more
wiley +1 more source
Stains Induce Apoptosis and Autophagy in Primary and Transformed Mast Cells [PDF]
, 2016 Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs) in patients with hypocholesteremia. In addition to their cholesterol-lowering effects through HMG CoA reductase antagonism, isoprenyl lipids necessary for ...
Paez, Patrick A
core +1 more source
Ferritin heavy chain Is the host factor responsible for HCV-Induced inhibition of apoB-100 production and is required for efficient viral infection [PDF]
, 2012 Hepatic fat export occurs by apolipoprotein B-100-containing lipoprotein production, whereas impaired production leads to liver steatosis. Hepatitis C virus (HCV) infection is associated to dysregulation of apoB-100 secretion and steatosis; however, the ...
AMICONE, Laura +9 more
core +3 more sources
Vox Sanguinis, EarlyView.Abstract Background and Objectives Patients with haematological malignancies are at high risk of anaemia due to disease and treatment factors, making patient blood management (PBM) strategies critical. We aimed to identify the barriers and enablers to implementing the principles of PBM to conserve patients' own blood and reduce the risk of iatrogenic ...
Courtney Black +3 more
wiley +1 more source
Optimizing the management of hereditary haemochromatosis: the value of MRI R2* quantification to predict and monitor body iron stores [PDF]
, 2017 This study was supported by a research Grant from the Teaching and Research Department of Centro Hospitalar do Porto (grant number DEFI:309/12(213-DEFI/251-CES). The funder had no role in study design, data collection and analysis, decision to publish or
Bayarri, ÁA +7 more
core +1 more source