Results 61 to 70 of about 7,733 (208)

Significance of iron reduction for the therapy of chronic hepatitis C [PDF]

Vojnosanitetski Pregled, 2005
Background. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload.
Nožić Darko, Balint Bela, Stanković Nebojša, Dimitrijević Jovan, Nešković Gorana   +4 more
doaj   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Hemodialysis International, EarlyView.
ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha, Richard Shamoon, Ameer Almeshagbeh, Samah Masry, Fadel Alqatati, Baha H. Abuajameia, Abdulqadir J. Nashwan   +6 more
wiley   +1 more source

A Detailed Protocol for the Induction of Anemia and RBC Transfusion–associated Necrotizing Enterocolitis in Neonatal Mice

Bio-Protocol
Anemia is a common and serious health problem, nearly universally diagnosed in preterm infants, and is associated with increased morbidity and mortality worldwide.
Balamurugan Ramatchandirin, Marie Amalie Balamurugan, Suneetha Desiraju, Yerin Chung, Mohan Krishnan   +4 more
doaj   +1 more source

Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB

ERJ Open Research, 2019
Therapeutic drug monitoring for drug-resistant tuberculosis (TB) is likely to improve treatment outcomes. While assessments of plasma drug levels can explain pharmacokinetic variability among trial participants, these measures require phlebotomy and a ...
John Metcalfe, Peter Bacchetti, Roy Gerona, Ali Esmail, Keertan Dheda, Monica Gandhi   +5 more
doaj   +1 more source

Iron Overload: Pathophysiology, Diagnosis and Monitoring

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Iron overload is associated with significant health risks, underscoring the importance of understanding its pathophysiology as well as establishing accurate diagnostic and monitoring methods. Chronic iron overload is associated with either genetic disorders characterized by excessive iron accumulation (hereditary hemochromatosis), or is ...
Elena Chatzikalil, Polyxeni Delaporta, Konstantinos Bistas, Antonis Kattamis   +3 more
wiley   +1 more source

Novel therapeutics in myeloproliferative neoplasms

Journal of Hematology & Oncology, 2020
Hyperactive signaling of the Janus-Associated Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) pathway is central to the pathogenesis of Philadelphia-chromosome-negative myeloproliferative neoplasms (MPN), i.e., polycythemia vera (PV),
Sangeetha Venugopal, John Mascarenhas
doaj   +1 more source

Effects of Oral Single‐Dose Empagliflozin on Urinary Glucose, Serum β‐Hydroxybutyrate, and Plasma Empagliflozin Concentrations in Healthy Adult Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Empagliflozin is a sodium‐glucose cotransporter‐2 inhibitor used for treating humans with heart failure, among other conditions. This drug could have applications in veterinary cardiology, but whether empagliflozin has biological effects in dogs when administered at dosages approximating human therapeutic dosages is unknown.
Andrea D. Plá Gutierrez, M. Lynne O'Sullivan, Etienne Côté, Sandra McConkey, Butch KuKanich, Stephanie E. Martinez   +5 more
wiley   +1 more source

Hereditary hemochromatosis: pathogenesis, symptoms, diagnosis and current treatment - literature review

Journal of Education, Health and Sport
Introduction: Hereditary hemochromatosis is the most common genetic disorder in Northern Europe. It involves an overload of iron in the tissues due to a deficiency of the protein hepcidin.
Dominika Prystacka-Szar, Natalia Rulewska, Filip Grabowski, Jakub Siemko, Dagmara Neska , Justyna Stadler-Szajda, Adrianna Czyżnikiewicz, Wenancjusz Stołowski, Magdalena Bujak, Magdalena Waśniowska   +9 more
doaj   +1 more source

Erythrocytapheresis versus phlebotomy in the initial treatment of HFE hemochromatosis patients: results from a randomized trial.

, 2011
Contains fulltext : 107773.pdf (Publisher’s version ) (Open Access)BACKGROUND: Standard treatment of newly diagnosed HFE hemochromatosis patients is phlebotomy.
Ferdinand Rombout, Cees Th.B.M. van Deursen, Essers, B.A., Paulus A.H. van Noord, Fred H.M. Nieman, Janssen, M.C.H., Ger H. Koek, Braak, R. ter, Rombout, F., Noord, P.A.H. van, Peter W. de Leeuw, Eva Rombout-Sestrienkova, Deursen, C.T. van, Essers, B.A.B., van Deursen, C.Th.B.M., Leeuw, P.W. de, Nieman, F.H.M., Brigitte A.B. Essers, van Noord, P.A.H., de Leeuw, P.W., Rombout-Sestrienkova, E., Nieman, F.H., Koek, G.H., van den Braak, R., Mirian C.H. Janssen, Bos, L.P., Laurens P. Bos, Rogier van den Braak   +27 more
core   +1 more source