Results 61 to 70 of about 7,496 (162)

Hereditary hemochromatosis: pathogenesis, symptoms, diagnosis and current treatment - literature review

Journal of Education, Health and Sport
Introduction: Hereditary hemochromatosis is the most common genetic disorder in Northern Europe. It involves an overload of iron in the tissues due to a deficiency of the protein hepcidin.
Dominika Prystacka-Szar, Natalia Rulewska, Filip Grabowski, Jakub Siemko, Dagmara Neska , Justyna Stadler-Szajda, Adrianna Czyżnikiewicz, Wenancjusz Stołowski, Magdalena Bujak, Magdalena Waśniowska   +9 more
doaj   +1 more source

Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Hemodialysis International, EarlyView.
ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha, Richard Shamoon, Ameer Almeshagbeh, Samah Masry, Fadel Alqatati, Baha H. Abuajameia, Abdulqadir J. Nashwan   +6 more
wiley   +1 more source

A phase 1b randomised clinical trial evaluating BBI-001, a non-absorbed oral therapeutic for the treatment of iron overload

Scientific Reports
Non-transfusion-dependent iron overload is the result of excessive dietary iron absorption, most commonly caused in populations of European descent by the genetic disorder HFE-related hemochromatosis (HH).
Curtis Scribner, Jamie Cope, Philip Ryan, John K. Olynyk, John Ryan, J. Daniel Griffin, Cory Berkland   +6 more
doaj   +1 more source

Impact of Heat Block Drying on Morphologic Preservation and Staining of Peripheral Blood Smears

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Morphologic evaluation of the peripheral blood smear is critical for diagnosis and ruling out certain hematologic disorders. While air‐drying is standard, some laboratories may use heat blocks to expedite drying. Excessive heat may induce morphologic artifacts, but there is a lack of systematic literature on this practice ...
Ryan C. Shean, Nicolas Mavromatis, Gary Isom, Angie Turnbow, Lauren Pearson   +4 more
wiley   +1 more source

Therapeutic Depletion of Iron Stores Is Not Associated with a Reduced Hemoglobin Mass in a Hemochromatosis Patient

Case Reports in Gastroenterology, 2016
Introduction: Hereditary hemochromatosis features a dysregulated iron absorption leading to iron overload and organ damage. The regulation of total hemoglobin mass during depletion of iron deposits by therapeutic phlebotomy has not been studied.
Nina Wrobel, Torben Pottgiesser, Philipp Birkner, Peter Deibert, Christoph Ahlgrim   +4 more
doaj   +1 more source

Novel therapeutics in myeloproliferative neoplasms

Journal of Hematology & Oncology, 2020
Hyperactive signaling of the Janus-Associated Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) pathway is central to the pathogenesis of Philadelphia-chromosome-negative myeloproliferative neoplasms (MPN), i.e., polycythemia vera (PV),
Sangeetha Venugopal, John Mascarenhas
doaj   +1 more source

Transfusion of blood products to neonatal and pediatric extracorporeal membrane oxygenation patients: A prospective, observational study

Transfusion, EarlyView.
Abstract Study Question To describe the blood product utilization during neonatal and pediatric extracorporeal membrane oxygenation (ECMO) and to determine whether its usage correlates with clinical outcomes of bleeding, thrombosis or mortality. Design Prospective observational study of neonatal and pediatric ECMO patients from September 2016, until ...
Rebecca Barton, Suelyn Van Den Helm, Hui Ping Yaw, Chantal Attard, Graeme MacLaren, Vera Ignjatovic, Natasha Letunica, Vasiliki Karlaftis, Tengyi Cai, Amy Johansen, Derek Best, Roberto Chiletti, Yves d'Udekem, Jo McKittrick, Warwick Butt, Paul Monagle   +15 more
wiley   +1 more source

Safety and tolerability of amustaline/glutathione pathogen‐reduced red blood cells in neonatal rats

Transfusion, EarlyView.
Abstract Background Amustaline (S‐303)/glutathione (GSH) pathogen‐reduced red blood cells (PR‐RBCs) are in development for all adult and pediatric RBC transfusion indications, including neonates and infants. A neonatal rat model evaluated the safety and tolerability of PR‐RBCs during growth and maturation. Study Design and Methods Repeated transfusions
Anne North, Laurence Corash, Richard J. Benjamin, Nina Mufti   +3 more
wiley   +1 more source

A Case Report of Prolonged Hemorrhage Following Traditional Phlebotomy (Fasd)

Journal of Pharmacopuncture
Phlebotomy, a therapeutic method of bloodletting typically performed using a needle, has a traditional technique known as “Fasd.” In this method, blood is extracted by creating a longitudinal incision on a vein (3-5 mm) with a surgical scalpel blade ...
Sajjad Sadeghi
doaj   +1 more source

Persistent Erythrocytosis in a Dog With a Spinal Sclerosing Paraganglioma

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 7‐year‐old, male, castrated, mixed‐breed dog presented with right pelvic limb lameness and pain on posturing to defecate that began 1.5 years prior to presentation. Radiographs taken 8 months prior to presentation showed a small lytic lesion of the L6 vertebral body, and CBCs showed a persistently increased hematocrit (HCT) for at least 2 ...
Samuel V. Neal, Samantha L. Sommer, Sarah Golconda, Eric T. Hostnik, Russell Sakacs, Janice Park, Ashley Potts, Ronaldo C. da Costa, Christopher Premanandan, Kara Corps, Sanggu Kim, Maxey L. Wellman   +11 more
wiley   +1 more source