Results 91 to 100 of about 1,909,516 (350)

Therapeutic Challenges Of Multi-Being [PDF]

open access: yes, 2008
This paper emerges from an attempt to shift the locus of understanding human action from the individual to relationship. In doing so we come to see persons as multi-beings, that is, as constituted within multiple relationships from which they emerge with
Anderson   +15 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

A slow unfolding at double speed. Therapeutic interventions with parents and their young children. [PDF]

open access: yes, 2008
Book Synopsis. This volume is the result of over twenty years of therapeutic interventions with families within the Tavistock Clinic's Under Fives Service.
Emanuel, Louise
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Comment les pères se représentent-ils leur engagement paternel et leur relation aux professionnel.le.s de la petite enfance ?

open access: yesEnfances, Familles, Générations, 2023
Research framework: It is now well documented that fathers are more involved than before in the care and education of their children, even if these involvements are not monolithic and depend on many contextual and internal family factors.
Cecilia Scacchitti   +2 more
doaj  

Conceptualization of Therapeutic Alliance During Psychiatric Residency Training [PDF]

open access: yes, 2011
This pilot study defines the Conceptualization of Therapeutic Alliance (CTA) as the psychotherapist\u27s internalized construct if his ideal patient-therapist relationship based on the principles if Therapeutic Alliance, Working Alliance, and Helping ...
Cozza, M.D., Stephen J.
core   +1 more source

Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]

open access: yes, 2019
Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J.   +10 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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