Results 131 to 140 of about 1,137,024 (297)
Enzyme Inhibitors as Therapeutic Tools
Biochemistry & Physiology: Open Access, 2012 The enzyme inhibition is valuable in the regulation of the enzyme activity. It has many applications, which include the drug design to target an enzyme. In the present review, we focus on the inhibition of different enzymes such as glycosidases, arylsulfatases and others by synthetic inhibitors or drugs.
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Microbial therapeutic tools for human brain disorders: A current overview
Brain DisordersDysbiosis and gut microbiome dysfunction are common phenomena that occur in several brain-related disorders. The application of treatments aimed at restoring the imbalance of the gut microbiome through the administration of psychobiotics, including ...
Alejandro Borrego-Ruiz, Juan J. Borrego
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Therapeutic antibody delivery: vector tools to boost efficacy and affordability
Frontiers in ImmunologyAntibody (Ab)-based therapeutics have become powerful tools across diverse disease areas, with advances in bioengineering giving rise to next−generation molecules designed to outperform conventional Abs.
Abhishek Chiyyeadu +11 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Aptamers as Potential Therapeutic Tools for Ovarian Cancer: Advancements and Challenges. [PDF]
Cancers (Basel), 2023 Szymanowski W +5 more
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Editorial: Stress neurobiology in COVID-19: diagnosis, neuroimaging and therapeutic tools. [PDF]
Front Neurol, 2023 Ferretti A +4 more
europepmc +1 more source
21st century social work: reducing re-offending - key practice skills [PDF]
, 2005 This literature review was commissioned by the Scottish Executive’s Social Work Services Inspectorate in order to support the work of the 21st Century Social Work Review Group.
Batchelor, S. +3 more
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