Bayesian data assimilation to support informed decision-making in individualized chemotherapy [PDF]
, 2020 An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes.
de Wiljes, Jana +4 more
core +2 more sources
Extracellular vesicles: Emerging tools as therapeutic agent carriers
Acta Pharmaceutica Sinica B, 2022 Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids, and metabolites from donor to recipient cells in cell-to-cell ...
Shan Liu +7 more
doaj +1 more source
New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]
, 2008 The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin +8 more
core +1 more source
Ewé: a web-based ethnobotanical database for storing and analysing data [PDF]
, 2020 Ethnobotanical databases serve as repositories of traditional knowledge (TK), either at international or local scales. By documenting plant species with traditional use, and most importantly, the applications and modes of use of such species ...
Hawkins, Julie A. +1 more
core +1 more source
Components of cell-matrix linkage as potential new markers for prostate cancer [PDF]
, 2011 Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment.
Eble, Johannes Andreas, Navdaev, Alexey
core +2 more sources
Extracellular Vesicles: From Biomarkers to Therapeutic Tools
Biology, 2020 Intercellular communication is an essential hallmark of multicellular organisms and can be mediated through direct cell–cell contact or transfer of secreted molecules. In the last two decades, a third mechanism for intercellular communication has emerged
Simona Bernardi, Carolina Balbi
doaj +1 more source
Pre-hospital management protocols and perceived difficulty in diagnosing acute heart failure [PDF]
, 2020 Aim To illustrate the pre-hospital management arsenals and protocols in different EMS units, and to estimate the perceived difficulty of diagnosing suspected acute heart failure (AHF) compared with other common pre-hospital conditions.
Banaszewski, Marek +77 more
core +1 more source
Designing stem cell niches for differentiation and self-renewal [PDF]
, 2018 Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in
Dalby, Matthew J. +2 more
core +1 more source
Exosomes and Exosomal miRNA in Respiratory Diseases [PDF]
, 2016 Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and ...
Adcock, IM +5 more
core +9 more sources
Dendrimers in gene delivery [PDF]
, 2005 Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also ...
Dufès, Christine +2 more
core +1 more source