Results 51 to 60 of about 1,137,024 (297)

Long non-coding RNAs: Key regulators of stemness in breast cancer

Frontiers in Cell and Developmental Biology
Among the different types of cancer, breast cancer is one of the most diagnosed and has the highest mortality rate in the global female population. While there are multiple approaches to current antineoplastic therapies targeting breast cancer, treatment
Olivia Tellez-Jimenez, Olivia Tellez-Jimenez, Alejandro Ordaz-Ramos, Marco Antonio Fonseca-Montaño, Karla Vazquez-Santillan   +4 more
doaj   +1 more source

Dendrimers as Potential Therapeutic Tools in HIV Inhibition

Molecules, 2013
The present treatments for HIV transfection include chemical agents and gene therapies. Although many chemical drugs, peptides and genes have been developed for HIV inhibition, a variety of non-ignorable drawbacks limited the efficiency of these ...
Xiangbo Li, Yi Chen, Xiaole Qi, Zhenghong Wu, Jianqing Peng   +4 more
doaj   +1 more source

Fluorescence-based proteasome activity profiling [PDF]

, 2012
With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Berkers, C.R., Jong, A., Ovaa, H., Rodenko, B., Schuurman, K.G.   +4 more
core   +1 more source

Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes [PDF]

, 2014
Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology.
Boissel, Jean-Pierre, Poret, Arnaud
core   +5 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

The Gut Microbiome in Enteric Viral Infections: Underlying Mechanisms and Therapeutic Approaches

Microorganisms
Despite growing recognition of the role of the gut microbiome in host health and in modulating pathogen activity, the dynamic and reciprocal relationship between enteric viruses and the gut microbial ecosystem remains insufficiently defined and requires ...
Alejandro Borrego-Ruiz, Juan J. Borrego
doaj   +1 more source

Phytochemical screening and inhibitory activity of oxalocalcic crystallization of Arbutus unedo L. leaves

Heliyon, 2018
The present study is focused on the experimental verification of the efficiency of Arbutus unedo L. leaves against the crystallization of calcium oxalate.
Rabie Kachkoul, Tarik Sqalli Houssaini, Radouane El Habbani, Youssef Miyah, Mohamed Mohim, Anissa Lahrichi   +5 more
doaj   +1 more source

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

CaMKII Inhibitors: From Research Tools to Therapeutic Agents

Frontiers in Pharmacology, 2014
The cardiac field has benefited from the availability of several CaMKII inhibitors serving as research tools to test putative CaMKII pathways associated with cardiovascular physiology and pathophysiology.
Patricia ePellicena, Howard eSchulman
doaj   +1 more source

BioMeT and algorithm challenges: A proposed digital standardized evaluation framework [PDF]

, 2020
Technology is advancing at an extraordinary rate. Continuous flows of novel data are being generated with the potential to revolutionize how we better identify, treat, manage, and prevent disease across therapeutic areas.
Aranda, Clara, Barreto, Marcos, Coravos, Andrea, Godfrey, Alan, Goldsack, Jennifer, Hussain,, Azid, Tenaerts, Pamela, Vitório, Rodrigo, Young, Fraser   +8 more
core   +4 more sources