Results 121 to 130 of about 3,734,628 (292)

Clients\u27 Internal Representations of Their Therapists [PDF]

open access: yes, 1999
Thirteen adults in long-term individual psychotherapy were interviewed regarding their internal representations (defined as bringing to awareness the internalized image ) of their therapists.
Goldberg, Julie L   +3 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Custo-efetividade dos análogos de nucleosídeos/nucleotídeos para hepatite crônica B Costo-efectividad de los análogos de nucleósidos/nucleótidos para hepatitis crónica B Cost-effectiveness of nucleoside/nucleotide analogues in chronic hepatitis B

open access: yesRevista de Saúde Pública, 2012
OBJETIVO: Conduzir uma análise de custo-efetividade das alternativas medicamentosas com terapia de resgate na recaída por resistência viral para tratamento de pacientes com hepatite crônica B (HCB).
Alessandra Maciel Almeida   +7 more
doaj  

Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. [PDF]

open access: yes, 2019
Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of active pathology is an obstacle to their clinical use.
Bertoni, Carmen   +6 more
core  

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reflexiones sobre las relaciones ciencia, tecnología, sociedad en el curso del proceso de investigación del óxido nítrico Reflections on the relationships between science, technology, and society throughout the research process of nitric oxide

open access: yesHumanidades Médicas, 2009
Se abordan la interrelación dialéctica entre la ciencia, la tecnología y la sociedad, y los estudios sobre el óxido nítrico en la fase preclínica. Los estudios de la ciencia, la tecnología y la sociedad permiten comprender la responsabilidad ética y ...
José L Cadena Freixas   +4 more
doaj  

Update on Generalized Pustular Psoriasis

open access: yesActa Médica Portuguesa
Generalized pustular psoriasis (GPP) is a rare but severe inflammatory skin disease characterized by the eruption of widespread sterile pustules, often accompanied by systemic inflammation.
Tiago Torres   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

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