Results 181 to 190 of about 3,734,628 (292)

The knowledge and attitude of pharmacists regarding the therapeutic use of cannabinoid-based medications in Jeddah, Saudi Arabia. [PDF]

Medicine (Baltimore)
Hareeri RH, Aldurdunji MM, Alamoudi AJ, Shazli TM, Ashour RM, Softa JF, Abusamra AA, Bagher AM.   +7 more
europepmc   +1 more source

Simple finite element models for use in the design of therapeutic footwear [PDF]

, 2014
Cavanagh, Peter R., Erdemir, Ahmet, Spaulding, Susan Ewers, Spirka, Thomas A., Telfer, Scott, Yamane, Ann   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Therapeutic Use and Potential of MSCs: Advances in Regenerative Medicine. [PDF]

Int J Mol Sci
Pînzariu AC, Moscalu R, Soroceanu RP, Maranduca MA, Drochioi IC, Vlasceanu VI, Timofeiov S, Timofte DV, Huzum B, Moscalu M, Serban DN, Serban IL.   +11 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Do not conflate debates on regulating therapeutic use of psychotropic substances with those on the legalization of their non-therapeutic use. [PDF]

Addiction
Zullino D.
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Volar Fibroblasts and their Potential Therapeutic Use. [PDF]

J Invest Dermatol
Lee SS, Garza LA.
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Therapeutic Use of Cannabis Derivatives and Their Analogs for Autism Spectrum Disorder: A Systematic Review. [PDF]

J Clin Pharmacol
Riera R, de Toledo IP, Farinasso CM, Pacheco RL, Silva RB, Colpani V, Martimbianco ALC, Cruz CM, Parreira PDCS, Latorraca COC.   +9 more
europepmc   +1 more source