Results 91 to 100 of about 28,229 (283)
The Dynamics of Knowledge Accumulation, Regulation and Appropriability in the Pharma-Biotech Sector: Policy Issues [PDF]
, 2006 Discussion of reasons for regulation in the pharmaceutical ...
Dosi, Giovanni +2 more
core
HElmet therapy Assessment in infants with Deformed Skulls (HEADS): protocol for a randomised controlled trial [PDF]
, 2012 Background In The Netherlands, helmet therapy is a commonly used treatment in infants with skull deformation (deformational plagiocephaly or deformational brachycephaly). However, evidence of the effectiveness of this treatment remains lacking. The HEADS
Boonekamp, M.M. +4 more
core +6 more sources
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2 [PDF]
, 2008 Background Homeodomain-interacting protein kinase-2 (HIPK2) plays an essential role in restraining tumor progression as it may regulate, by itself or within multiprotein complexes, many proteins (mainly transcription factors) involved in cell growth and ...
Rosa Puca +2 more
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Fecal microbiota transplantation: therapeutical approaches and regulatory framework
Биопрепараты: Профилактика, диагностика, лечение, 2018 Since Ilya Metchnikoff’s studies, both medical science and clinical practice have accumulated a large amount of evidence that human intestinal microbiota possesses a unique characteristics for our existence.
A. N. Vasilyev +5 more
doaj
Ritmos biológicos no homem. Aspectos particulares em medicina.
Acta Médica Portuguesa, 1993 The concepts of chronobiology and chronopharmacology have become more and more important in medical practice nowadays. Today, the circadian variation in blood pressure and heart rate as well as in the occurrence of acute cardiovascular disease is quite ...
P M da Silva, F L Nobre
doaj +1 more source
Pre-embryo: Therapeutic Approaches
Annals of Medicine, 1993 There are potential interventions in the pre-embryo stage in order to improve the clinical results of assisted reproductive technology, live-birth per cycle of treatment, and to prevent the birth of offspring with genetic aberrations. The following therapeutic measures can be potentially applied to the pre-embryo: improvement of culture conditions, pre-
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Reumatismo, 2013 Pachydermoperiostosis as the primary form of hypertrophic osteoarthropathy is a rare hereditary disorder with a number of characteristic findings, e.g. periosteal hypertrophy, digital clubbing and pachydermia.
S. Warwas +3 more
doaj +1 more source