Results 1 to 10 of about 1,127,945 (343)
Pharmacists in clozapine clinics improving physical health monitoring [PDF]
Mental Health Clinician, 2022 Introduction: People living with schizophrenia have a higher rate of comorbid physical health diseases and compared with the general population die earlier due to these diseases.
Greg Spann, BPharm, GCert Psychiatric Therapeutics +2 more
doaj +1 more source
Macrophages in immunoregulation and therapeutics
Signal Transduction and Targeted Therapy, 2023 Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.
Shanze Chen +7 more
semanticscholar +1 more source
Noncoding RNA therapeutics — challenges and potential solutions
Nature reviews. Drug discovery, 2021 Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of cancers, as well as many other diseases.
Melanie Winkle +3 more
semanticscholar +1 more source
Chemistry, structure and function of approved oligonucleotide therapeutics
Nucleic Acids Research, 2023 Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), RNA interference (RNAi) and an RNA ...
M. Egli, M. Manoharan
semanticscholar +1 more source
NANOBODIES®: A Review of Generation, Diagnostics and Therapeutics
International Journal of Molecular Sciences, 2023 NANOBODY® (a registered trademark of Ablynx N.V) molecules (Nbs), also referred to as single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG antibodies found in the Camelidae family.
Bo Jin +3 more
semanticscholar +1 more source
Neurointervention in the Era of COVID-19: Korean Nationwide Survey, Literature Review, and Recommendations [PDF]
Neurointervention, 2021 The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a tremendous impact on healthcare systems worldwide. Although the most common presentation of COVID-19 is respiratory illness,
Woong Jae Lee, Jun Soo Byun
doaj +1 more source
Engineering protein-based therapeutics through structural and chemical design
Nature Communications, 2023 Ebrahimi and Samanta review the key advances in the chemical and structural modification of proteins that have enabled their rise as indispensable tools in medicine and outline emerging protein engineering strategies that can potentially unlock ...
Sasha B. Ebrahimi, Devleena Samanta
semanticscholar +1 more source
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Respiratory Research, 2021 Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs.
Martin L. Decaris +27 more
doaj +1 more source
Journal of Neuroinflammation, 2021 Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinflammation.
Susana S. Correia +16 more
doaj +1 more source
Oncogenesis, 2023 Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of inhibitory ...
Zhao Chen +25 more
doaj +1 more source