Results 1 to 10 of about 1,188,443 (357)

Pharmacists in clozapine clinics improving physical health monitoring [PDF]

open access: yesMental Health Clinician, 2022
Introduction: People living with schizophrenia have a higher rate of comorbid physical health diseases and compared with the general population die earlier due to these diseases.
Greg Spann, BPharm, GCert Psychiatric Therapeutics   +2 more
doaj   +1 more source

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

open access: yesRespiratory Research, 2021
Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs.
Martin L. Decaris   +27 more
doaj   +1 more source

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

open access: yesJournal of Neuroinflammation, 2021
Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinflammation.
Susana S. Correia   +16 more
doaj   +1 more source

2019 Overview [PDF]

open access: yes, 2020
The CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews, and reports of novel findings of therapeutic relevance to the central nervous system.
Boltze, Johannes   +8 more
core   +1 more source

Changes in Prevalence and Treatment Pattern of Benign Prostatic Hyperplasia in Korea [PDF]

open access: yesInternational Neurourology Journal, 2021
Purpose Benign prostatic hyperplasia (BPH) is associated with lower urinary tract symptoms and negatively affects the quality of life. We aimed to investigate the treatment pattern of BPH in South Korea.
Jung Ki Jo   +3 more
doaj   +1 more source

An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria

open access: yesMolecular Systems Biology, 2022
Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and kidney failure. There are no approved pharmaceutical treatments for EH.
David Lubkowicz   +13 more
doaj   +1 more source

Conversational Agents in Therapeutic Interventions for Neurodevelopmental Disorders: A Survey [PDF]

open access: yes, 2021
Neurodevelopmental Disorders (NDD) are a group of conditions with onset in the developmental period characterized by deficits in the cognitive and social areas. Conversational agents have been increasingly explored to support therapeutic interventions for people with NDD.
arxiv   +1 more source

Phycological debriefing in acute traumatic events: Evidence synthesis

open access: yesMedwave, 2022
Stressful life situations can generate chronic symptomatology, so it is of great concern to analyze preventive strategies. Psychological debriefing is an intervention for acute trauma, which verbalizes perceptions, thoughts, and emotions experienced ...
Marcelo Arancibia   +6 more
doaj   +1 more source

Big Hopes with Small Molecules – PIQUR Therapeutics AG is aiming to Turn Cancer into a Manageable Disease [PDF]

open access: yes, 2014
The origins of PIQUR Therapeutics AG, which was established in 2011, are found in significant research work at the University of Basel. The main focus of the spin-off of the University of Basel is the active pharmaceutical ingredient PQR309, which was ...
PIQUR Therapeutics AG
core   +2 more sources

Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response

open access: yesOncogenesis, 2023
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of inhibitory ...
Zhao Chen   +25 more
doaj   +1 more source

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