Results 1 to 10 of about 872,419 (247)

Pharmacists in clozapine clinics improving physical health monitoring [PDF]

open access: yesMental Health Clinician, 2022
Introduction: People living with schizophrenia have a higher rate of comorbid physical health diseases and compared with the general population die earlier due to these diseases.
Greg Spann, BPharm, GCert Psychiatric Therapeutics   +2 more
doaj   +1 more source

Effectiveness of Acceptance and Commitment Therapy in Reducing High-risk and Harmful Behaviors in Students [PDF]

open access: yesمجله علوم پزشکی صدرا, 2023
Introduction: The prevalence of high-risk behaviors in young people is one of the concerns of societies. This study aimed to evaluate the effectiveness of Acceptance and Commitment therapy in reducing high-risk and harmful behaviors among high school ...
Zahra Alizadeh, Abbas Rohani
doaj   +1 more source

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

open access: yesRespiratory Research, 2021
Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs.
Martin L. Decaris   +27 more
doaj   +1 more source

Therapeutic effects of diosgenin on alveolar bone loss and apoptosis in diabetic rats with experimental periodontitis [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2023
Objective(s): The present study aims to evaluate the efficacy of administered diosgenin (DG) which has anti-oxidant and anti-inflammatory effects, on alveolar bone loss (ABL) and apoptosis in diabetic rats with periodontitis. Materials and Methods: Forty
Alper Kızıldağ   +4 more
doaj   +1 more source

Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response

open access: yesOncogenesis, 2023
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of inhibitory ...
Zhao Chen   +25 more
doaj   +1 more source

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

open access: yesJournal of Neuroinflammation, 2021
Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinflammation.
Susana S. Correia   +16 more
doaj   +1 more source

Engineering of a trispecific tumor-targeted immunotherapy incorporating 4-1BB co-stimulation and PD-L1 blockade

open access: yesOncoImmunology, 2021
Co-stimulatory 4–1BB receptors on tumor-infiltrating T cells are a compelling target for overcoming resistance to immune checkpoint inhibitors, but initial clinical studies of 4–1BB agonist mAbs were accompanied by liver toxicity. We sought to engineer a
Stefan Warmuth   +23 more
doaj   +1 more source

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

open access: yesJournal of Nanotheranostics, 2023
Nanomaterial-based tissue engineering strategies are precisely designed and tweaked to contest specific patient needs and their end applications. Though theragnostic is a radical term very eminent in cancer prognosis, of late, theragnostic approaches ...
Kaushita Banerjee   +1 more
doaj   +1 more source

An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria

open access: yesMolecular Systems Biology, 2022
Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and kidney failure. There are no approved pharmaceutical treatments for EH.
David Lubkowicz   +13 more
doaj   +1 more source

Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics

open access: yesBiomedicines, 2023
Bacterial Extracellular Vesicles (BEVs) possess the capability of intracellular interactions with other cells, and, hence, can be utilized as an efficient cargo for worldwide delivery of therapeutic substances such as monoclonal antibodies, proteins ...
Ashok Iyaswamy   +10 more
doaj   +1 more source

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