Materia Medica, Pharmacology, Therapeutics and Prescription Writing for Students and Practitioners. [PDF]
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The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua+5 more
wiley +1 more source
Pharmacology, Clinical and Experimental. A Groundwork of Medical Treatment. By H. H. Meyer and R. Gottlieb, Professors of Pharmacology at Vienna and Heidelberg; Translated by J. T. Halsey, Professor of Pharmacology, Therapeutics, and Clinical Medicine at Tulane University. Pp. 604; 64 illustrations. Philadelphia and London [PDF]
E. B. K.
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Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng+12 more
wiley +1 more source
The Goulstonian Lectures on Pharmacology and its Relation to Therapeutics [PDF]
T. L. Brunton
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Structured, Shaped, or Printed Single‐Atom Catalysts and Their Applications
This paper reviews the design and use of structured single‐atom catalysts, which integrate porous architectures with the exceptional reactivity of isolated catalytic sites. It explores fabrication strategies, advanced characterization methods, and support materials that enhance thermal stability, mechanical robustness, and operational efficiency of ...
Jiachengjun Luo+4 more
wiley +1 more source
SIU: A Million-Scale Structural Small Molecule-Protein Interaction Dataset for Unbiased Bioactivity Prediction [PDF]
Small molecules play a pivotal role in modern medicine, and scrutinizing their interactions with protein targets is essential for the discovery and development of novel, life-saving therapeutics. The term "bioactivity" encompasses various biological effects resulting from these interactions, including both binding and functional responses.
arxiv
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang+9 more
wiley +1 more source
MiranDa: Mimicking the Learning Processes of Human Doctors to Achieve Causal Inference for Medication Recommendation [PDF]
To enhance therapeutic outcomes from a pharmacological perspective, we propose MiranDa, designed for medication recommendation, which is the first actionable model capable of providing the estimated length of stay in hospitals (ELOS) as counterfactual outcomes that guide clinical practice and model training.
arxiv