Antimalarial pharmacology and therapeutics of atovaquone [PDF]
Journal of Antimicrobial Chemotherapy, 2013 Atovaquone is used as a fixed-dose combination with proguanil (Malarone) for treating children and adults with uncomplicated malaria or as chemoprophylaxis for preventing malaria in travellers. Indeed, in the USA, between 2009 and 2011, Malarone prescriptions accounted for 70% of all antimalarial pre-travel prescriptions.
David G. Lalloo +7 more
openaire +4 more sources
Machine-learning Analysis of Opioid Use Disorder Informed by MOR, DOR, KOR, NOR and ZOR-Based Interactome Networks [PDF]
arXiv, 2023 Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to potential abuse. Despite that a few pharmacological agents have been approved for OUD treatment, the efficacy of said agents for OUD requires further improvement in order to provide safer and ...
arxiv
Liposomes versus metallic nanostructures: differences in the process of knowledge translation in cancer [PDF]
International Journal of Nanomedicine. 2014; 9: 2627-2634, 2016 This research maps the knowledge translation process for two different types of nanotechnologies applied to cancer: liposomes and metallic nanostructures (MNs). We performed a structural analysis of citation networks and text mining supported in controlled vocabularies.
arxiv +1 more source
Journal of Pharmaceutical Health Care and Sciences, 2023 Background Drug-drug interaction management is complex. Nirmatrelvir/ritonavir is a potent cytochrome P450 (CYP) 3A inhibitor and influences pharmacokinetics of co-administered drugs.
Ayumi Tsuzawa +11 more
doaj +1 more source
Cognitive Impairment Associated with Schizophrenia: Toward Novel Therapeutics.
Annual Review of Pharmacology and Toxicology, 2022 Cognitive impairment is a core feature of schizophrenia and a major contributor to poor functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are now well established. In addition, there has been increasing appreciation in
D. Javitt
semanticscholar +1 more source
Network Pharmacology, Molecular Docking, and MR Analysis: Targets and Mechanisms of Gegen Qinlian Decoction for Helicobacter pylori [PDF]
arXiv, 2023 Objective: The study explored therapeutic targets and mechanisms of Gegen Qinlian Decoction for Helicobacter pylori infection and related gastric cancer using network pharmacology, molecular docking, and Mendelian randomization. Methods: Medicinal components of Gegen Qinlian Decoction were extracted from TCMSP and HERB databases.
arxiv
Future Journal of Pharmaceutical Sciences, 2022 Researchers now have a new avenue to investigate when it comes to miRNA-based therapeutics. miRNAs have the potential to be valuable biomarkers for disease detection.
Atiya Saiyed, A. Vasavada, S. Johar
semanticscholar +1 more source
Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida [PDF]
, 2017 Pharmacokinetic–pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules of oxytetracycline for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida.
Aliabadi +34 more
core +1 more source
Proceedings, 2021 Introduction: Cassia fistula has anti-inflammatory activity. Rheumatoid arthritis (RA) is an autoimmune disease, causing inflammation and disability of the affected joints.
Mariyam Iftikhar Piracha +4 more
doaj +1 more source
Protein-ligand interaction study to identify potential dietary compounds binding at the active site of therapeutic target proteins of SARS-CoV-2 [PDF]
arXiv, 2020 Objective: Total 186 biologically important phenylpropanoids and polyketides compounds from different Indian medicinal plants and dietary sources were screened to filter potential compounds that bind at the active site of the therapeutic target proteins of SARS-CoV-2.
arxiv