Results 31 to 40 of about 1,549,234 (325)

Psychedelics as Transformative Therapeutics.

American Journal of Psychiatry, 2023
Over the past decade, psychedelic compounds have emerged as potentially transformative therapeutics for a variety of intractable neuropsychiatric conditions.
B. Roth, R. Gumpper
semanticscholar   +1 more source

α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries [PDF]

, 2013
The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved.
Alexander, Arévalo-León, Cavalli, Chalothorn, Chen, Cotecchia, Daly, Deighan, Docherty, García-Cazarín, García-Sainz, García-Sainz, García-Sainz, Gisbert, Gisbert, Gisbert, Gisbert, Goldstein, Hawrylyshyn, Hein, Hosoda, Hrometz, Hussain, Keffel, Kenny, Koshimizu, Lachnit, Lyssand, Lyssand, Lyssand, Martinez-Rivelles, Martí, McCune, Methven, Methven, Michelotti, Monto, Noguera, Noguera, Philipp, Piascik, Piascik, Pérez-Aso, Rudner, Schwinn, Stassen, Taguchi, Tanaka, Tanoue, Tanoue, Theroux, Yamamoto, Zhong, Ziani   +53 more
core   +1 more source

USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP

Nature Communications, 2020
C-terminal binding protein (CtBP) interacting protein (CtIP) is a fundamental factor for the initiation of DNA end resection to initiate DNA repair. Here the authors reveal mechanistic insights into the regulation of CtIP via the deubiquitinase USP52.
Ming Gao, Guijie Guo, Jinzhou Huang, Jake A. Kloeber, Fei Zhao, Min Deng, Xinyi Tu, Wootae Kim, Qin Zhou, Chao Zhang, Ping Yin, Kuntian Luo, Zhenkun Lou   +12 more
doaj   +1 more source

Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats

Fluids and Barriers of the CNS, 2021
Background Adenosine triphosphate binding cassette transporters such as P-glycoprotein (PGP) play an important role in drug pharmacokinetics by actively effluxing their substrates at barrier interfaces, including the blood-brain, blood-cerebrospinal ...
Liam M. Koehn, Katarzyna M. Dziegielewska, Mark D. Habgood, Yifan Huang, Norman R. Saunders   +4 more
doaj   +1 more source

Clinical Pharmacology and Therapeutics [PDF]

, 2016
Pharmacotherapeutics is an important element of space medicine practice. Assessing health risks, developing countermeasures, selecting relevant supplies for medical kits and providing appropriate training for crew members on the use of medical kits prior to the mission start are all major contributors of mission success.
Putcha, L, Taylor, PW, Daniels, VR, Pool, SL   +3 more
openaire   +2 more sources

Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep [PDF]

, 2015
Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of
A., Di Salvo, Bortolami, Elisa, DE BENEDICTIS, GIULIA MARIA, G., della Rocca, Isola, Maurizio, M., Giorgi, T. W., Kim   +6 more
core   +1 more source

Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study

Clinical pharmacology and therapy, 2018
Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of a uniform high standard.
D. Brinkman, J. Tichelaar, L. Mokkink, T. Christiaens, R. Likić, R. Mačiulaitis, João N. Costa, E. Sanz, S. Maxwell, M. Richir, M. V. van Agtmael, Romain Ivanka Maria Ivanka Emil Gayla Dinko Suzana Greta Lefebvre Kostadinova Ganeva Atanasova Gatchev Stav, Romain Lefèbvre, Iva S. Kostadinova, M. Ganeva, I. Atanasova, E. Gatchev, G. Stavreva, D. Vitezić, S. Matanović, G. Wozniak, Persoulla A. Nicolaou, K. Urbánek, O. Slanař, E. Kmoníčková, R. Demlova, T. Bergmann, P. Damkier, A. Kalda, R. Huupponen, J. Backman, M. Drici, D. Deplanque, M. Molimard, E. Toussirot, Y. Pers, P. Bertin, B. Laviolle, C. Le Jeunne, P. Saulnier, B. Chamontin, M. Roustit, D. Orlikowski, Nicolas Simon, P. Dequin, T. Angoulvant, Juliane Bolbrinker, L. Wojnowski, I. Cascorbi, Frank Müller, S. Müller, M. Schwaninger, J. Neumann, F. Stümpel, R. Regenthal, U. Fuhr, P. Thürmann, A. Eirini, Paraskevi Papaioannidou, D. Kouvelas, G. Kolios, P. Riba, D. Kerins, David Williams, A. Harnett, E. Spina, G. Fumagalli, A. Filippelli, S. Benemei, F. De Ponti, M. Cosentino, V. Locatelli, M. D. De Montis, M. Memo, E. Raschi, S. Purviņa, J. Gulbinovič, J. Mifsud, K. Keijsers, R. Rissmann, G. Dumont, F. van Rosse, O. Spigset, M. S. Opdal, J. Braszko, D. Mirowska-Guzel, M. Broncel, I. Kocić, M. C. Sousa, E. Monteiro, L. Dima, I. Magyar, S. Conea, A. Buzoianu, H. Glasová, J. Tisoňová, Josef Glasa, M. Kržan, Joaquín Sáez-Peñataro, F. J. de Abajo Iglesias, D. Capellà, F. Figuerola, A. C. Sansuán, M. López-Rico, G. Manso, Julio Benitez, M. Lucena, M. L. Bernal, X. C. Cladellas, Ruthi Hernandez, C. Pontes, G. Panagiotidis, Y. Böttiger, S. Wallerstedt, A. Eriksson, J. Desmeules, S. Krähenbühl, Rick Plumb, M. Okorie, K. Wilson, G. Mckay, R. Sofat, V. Kapil, J. Whitfield, R. Thanacoody, Fraz Mir, Y. Loke, M. Schachter, Lauren O'brien, A. Heep   +129 more
semanticscholar   +1 more source

Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease [PDF]

, 2014
Background: There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n−3 polyunsaturated fatty acid, could prevent Crohn's disease (CD).
Abraham, Ananthakrishnan, Ananthakrishnan, Ananthakrishnan, Arita, Bartoli, Belluzzi, Bingham, Burdge, Chan, Charpentier, Corey, Depner, Feagan, Fritsche, Goldbohm, Goldman, Hommes, Jostins, Kaaks, Levy, Novak, Rao, Riboli, Rodriguez-Lagunas, Sakamoto, Salem, Samuelsson, Serhan, Serini, Shivananda, Tjonneland, Turner, Watanabe, Weylandt, Yaqoob   +35 more
core   +1 more source

Pharmacology and Therapeutics Education in the European Union Needs Harmonization and Modernization: A Cross‐sectional Survey Among 185 Medical Schools in 27 Countries

Clinical pharmacology and therapy, 2017
Effective teaching in pharmacology and clinical pharmacology and therapeutics (CPT) is necessary to make medical students competent prescribers. However, the current structure, delivery, and assessment of CPT education in the European Union (EU) is ...
D. Brinkman, J. Tichelaar, M. Okorie, L. Bissell, T. Christiaens, R. Likić, R. Mačiulaitis, José Costa, E. J. Sanz, B. Tamba, S. Maxwell, M. Richir, M. V. Agtmael   +12 more
semanticscholar   +1 more source

Forensic pharmacology: An important and evolving subspecialty needs recognition in India

Journal of Pharmacy and Bioallied Sciences, 2016
With training in pharmacology, a pharmacologist has an expert knowledge as well as working experience in the subjects of therapeutics, pharmacokinetics, and toxicology along with exposure to subjects such as forensic medicine during the medical education.
Harshad Onkarrao Malve
doaj   +1 more source