Results 41 to 50 of about 1,549,234 (325)
Process Improvement for Maximized Therapeutic Innovation Outcome. [PDF]
, 2017 Deconvoluting key biological mechanisms forms the framework for therapeutic discovery. Strategies that enable effective translation of those insights along the development and regulatory path ultimately drive validated clinical application in patients ...
Terzic, Andre, Waldman, Scott A.
core +2 more sources
Biochemical Pharmacology, 2018 Graphical abstract Figure. No Caption available. ABSTRACT The endocannabinoid system (ECS) exerts a modulatory effect of important functions such as neurotransmission, glial activation, oxidative stress, or protein homeostasis.
M. Aymerich +7 more
semanticscholar +1 more source
Novel perspectives in redox biology and pathophysiology of failing myocytes: modulation of the intramyocardial redox milieu for therapeutic interventions - A review article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology [PDF]
, 2016 The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogeneticmechanisms and in developing effective therapies that have transformed this ...
Angelini, Annalisa +8 more
core +9 more sources
ATP as a presynaptic modulator [PDF]
, 2000 © 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core +1 more source
Bulletin of the National Research Centre, 2022 Background Eragrostis tremula Hochst. ex Steud. (Poaceae) is used in ethno-medicine as a memory enhancer. Studies have shown that the whole plant possesses memory enhancing potentials and could be beneficial in the management of amnesia and cognitive ...
Abdullahi Balarabe Nazifi +4 more
doaj +1 more source
Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit [PDF]
, 2013 Cephalexin is a first generation cephalosporin widely used in rabbits. Its spectrum includes Pasteurella multocida and Staphylococcus aureus. These bacteria, together with Bordetella bronchiseptica, are the main cause of respiratory infections.
Albarellos, Gabriela Alejandra +2 more
core +2 more sources
Frontiers in Physiology, 2021 Mathematical biology and pharmacology models have a long and rich history in the fields of medicine and physiology, impacting our understanding of disease mechanisms and the development of novel therapeutics.
Karim Azer +12 more
doaj +1 more source
F1000Research, 2020 Background: Paracetamol (acetaminophen) is widely used in pregnancy and generally regarded as “safe” by regulatory authorities. Methods: Clinically relevant doses of paracetamol were administered intraperitoneally to pregnant rats twice daily from ...
Liam M. Koehn +6 more
doaj +1 more source
Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. [PDF]
, 2019 Background: The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice.
Abraham, Tara S. +9 more
core +3 more sources
Nature Communications, 2023 Dietary glycans are a major driver of the human gut microbiota composition. Here, the authors apply next-generation metabolic labeling coupled with fluorescence-activated cell sorting to identify and isolate gut bacteria consumers of dietary glycans in ...
Lharbi Dridi +10 more
doaj +1 more source