Results 21 to 30 of about 327,430 (289)

Ameliorative effect of ethanol extract of Eragrostis tremula Hochst. ex Steud. against diazepam-induced amnesia in mice

Bulletin of the National Research Centre, 2022
Background Eragrostis tremula Hochst. ex Steud. (Poaceae) is used in ethno-medicine as a memory enhancer. Studies have shown that the whole plant possesses memory enhancing potentials and could be beneficial in the management of amnesia and cognitive ...
Abdullahi Balarabe Nazifi, Abdulhakim Abubakar, Mohammed Garba Magaji, Musa Aliyu, Nuhu Mohammed Danjuma   +4 more
doaj   +1 more source

The use of structured assessments, practical skills and performance indicators to assess the ability of pre-registration nursing students to apply the principles of pharmacology and therapeutics to the medication management needs of patients

, 2003
This paper discusses how structured assessments, practical skills and performance indicators can be used to assess the ability of pre-registration nursing students’ to analyze and clinically apply the theoretical principles of pharmacology and ...
Banning, M, Maggi Banning, Banning, M.
core   +1 more source

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain [version 2; peer review: 2 approved]

F1000Research, 2020
Background: Paracetamol (acetaminophen) is widely used in pregnancy and generally regarded as “safe” by regulatory authorities. Methods: Clinically relevant doses of paracetamol were administered intraperitoneally to pregnant rats twice daily from ...
Liam M. Koehn, Yifan Huang, Mark D Habgood, Kai Kysenius, Peter J. Crouch, Katarzyna M Dziegielewska, Norman R Saunders   +6 more
doaj   +1 more source

History and Future Perspectives on the Discipline of Quantitative Systems Pharmacology Modeling and Its Applications

Frontiers in Physiology, 2021
Mathematical biology and pharmacology models have a long and rich history in the fields of medicine and physiology, impacting our understanding of disease mechanisms and the development of novel therapeutics.
Karim Azer, Chanchala D. Kaddi, Jeffrey S. Barrett, Jane P. F. Bai, Sean T. McQuade, Nathaniel J. Merrill, Benedetto Piccoli, Susana Neves-Zaph, Luca Marchetti, Rosario Lombardo, Silvia Parolo, Selva Rupa Christinal Immanuel, Nitin S. Baliga   +12 more
doaj   +1 more source

Optimizing Oncology Therapeutics Through Quantitative Translational and Clinical Pharmacology: Challenges and Opportunities

, 2015
Despite advances in biomedical research that have deepened our understanding of cancer hallmarks, resulting in the discovery and development of targeted therapies, the success rates of oncology drug development remain low.
DR Mould, K Venkatakrishnan, Troconiz, I. F., R Bruno, Mehrotra, N., Friberg, Lena E.,, Mould, D. R., Venkatakrishnan, K., IF Trocóniz, Mettetal, J. T., A Stein, Stein, A., N Mehrotra, Ouellet, D., LE Friberg, D Ouellet, Gobburu, J., JT Mettetal, J Gobburu, Bruno, R.   +19 more
core   +1 more source

The pharmacology and therapeutic potential of (-)-huperzine A

Journal of Experimental Pharmacology, 2012
(-)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (-)-huperzine A (1).
Tun,Maung Kyaw Moe, Herzon,Seth B
openaire   +4 more sources

Identifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting

Nature Communications, 2023
Dietary glycans are a major driver of the human gut microbiota composition. Here, the authors apply next-generation metabolic labeling coupled with fluorescence-activated cell sorting to identify and isolate gut bacteria consumers of dietary glycans in ...
Lharbi Dridi, Fernando Altamura, Emmanuel Gonzalez, Olivia Lui, Ryszard Kubinski, Reilly Pidgeon, Adrian Montagut, Jasmine Chong, Jianguo Xia, Corinne F. Maurice, Bastien Castagner   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Muscle‐directed gene therapy corrects Pompe disease and uncovers species‐specific GAA immunogenicity

EMBO Molecular Medicine, 2021
Pompe disease is a severe disorder caused by loss of acid α‐glucosidase (GAA), leading to glycogen accumulation in tissues and neuromuscular and cardiac dysfunction. Enzyme replacement therapy is the only available treatment. AT845 is an adeno‐associated
Michelle Eggers, Charles H Vannoy, Jianyong Huang, Pravinkumar Purushothaman, Jacqueline Brassard, Carlos Fonck, Hui Meng, Mariah J Prom, Michael W Lawlor, Justine Cunningham, Chanchal Sadhu, Fulvio Mavilio   +11 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source