Results 171 to 180 of about 797,768 (317)
When Software Becomes Medicine: Ignoring It May Soon Be Malpractice. [PDF]
CureusLakhan SE.
europepmc +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1117-1131, April 2025.This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto +3 more
wiley +1 more source
Beyond Efficacy: Ensuring Safety in Peptide Therapeutics through Immunogenicity Assessment. [PDF]
J Pept SciAchilleos K +3 more
europepmc +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores +14 more
wiley +1 more source
Therapeutics and Clinical Risk Management - 20<sup>th</sup> Anniversary. [PDF]
Ther Clin Risk ManagWalsh GM, Wang Y.
europepmc +1 more source