Results 151 to 160 of about 1,055,467 (319)
The changing face of cancer therapeutics improved : outcome and decreased toxicity with Molecular Targeted Drugs [PDF]
, 2004 The treatment of patients with cancer has largely involved the administration of cytotoxic drugs with narrow therapeutic indices, with little selectivity for cancer cells over normal proliferating cells.
De Bono, Johann S., Attard, Gerhardt
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2002 Therapeutics Letter 45 considers the value of single stereoisomer drugs. Stereoisomers are molecules with one or more “chiral” centres that allow the possibility of forms with the same chemical formula but differing spatial arrangements. The concept that
Therapeutics Initiative (University of British Columbia)
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2001 Therapeutics Letter 42 explores the reporting of serious adverse events (SAEs) using examples from lipid-lowering trials. Conclusions: Total %SAEs is an important measure of the health impact of a drug.
Therapeutics Initiative (University of British Columbia)
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2019 Therapeutics Letter 119 discusses epinephrine autoinjectors available in Canada. Conclusions People at risk for anaphylaxis in the outpatient setting should be advised to have access to at least two epinephrine autoinjectors especially when they are far ...
Therapeutics Initiative (University of British Columbia)
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2005 Therapeutics Letter 56 examines drugs for Alzheimer's disease. Conclusions: Donepezil has not been demonstrated to improve outcomes of importance to patients and caregivers (e.g. institutionalization or disability).
Therapeutics Initiative (University of British Columbia)
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