Results 141 to 150 of about 1,064,547 (319)
Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets
MedCommThe substantial loss of cardiomyocytes resulting from myocardial infarction leads to pathological remodeling of the heart and the onset of heart failure.
Mingchuan Liu +9 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
, 2001 Therapeutics Letter 41 considers treatment of asymptomatic bacteriuria in pregnancy using Cochrane systematic review evidence. Reliable sources of best available evidence are an aid to practice.
Therapeutics Initiative (University of British Columbia)
core
The Interplay of Aging and Cancer: Mechanisms, Implications, and Therapeutic Strategies
MedComm – OncologyAging is a complex biological process that significantly influences human health, including susceptibility to cancer. Although aging and cancer are distinct phenomena, they intersect through shared molecular mechanisms such as genomic instability ...
Liangce Wang +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 1996 Therapeutics Letter 14 discusses menopausal hormone therapy. Education, support and non-drug therapies are essential for all menopausal women. Short-term hormone therapy has a useful role in selected women with established symptoms or disease.
Therapeutics Initiative (University of British Columbia)
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
, 2003 Therapeutics Letter 50 examines evidences for blood pressure lowering from the DASH trials. Substantial BP lowering can be achieved by a reduced dietary sodium intake, the DASH diet, or a combination of the two.
Therapeutics Initiative (University of British Columbia)
core
Therapeutic atmospheres. The aesthetics of therapeutic spaces
Lebenswelt. Aesthetics and philosophy of experience.This article explores the spatial dimensions of selfhood and the pathic felt-bodily resonance, emphasizing their role in understanding the connection between health and the environment. Adopting a phenomenological perspective, it provides an overview of the relationship between embodiment, spatiality, and affectivity and their alterations in mental ...
openaire +3 more sources