Results 121 to 130 of about 1,055,467 (319)
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Aumento del uso de nuevos antipsicóticos en niños: ¿Debemos preocuparnos?
Evidencia. Actualización en la Práctica Ambulatoria, 2010 nan Therapeutics Initiative
doaj +1 more source
, 2021 Therapeutics Letter 133 evaluates optimal treatments for primary hypertension using Cochrane systematic review evidence. Conclusions: Low-dose thiazides are the best drug class for starting antihypertensive therapy.
Therapeutics Initiative (University of British Columbia)
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
, 1998 Therapeutics Letter 27 summarizes the findings of six randomized controlled trials (RCTs) and synthesizes the evidence from these trials in the context of previous letters relating to treatment of hypertension (Letters 7, 8, 9, 16), Type 2 diabetes ...
Therapeutics Initiative (University of British Columbia)
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2009 Therapeutics Letter 74 examines the increasing use of antipsychotics in children. The use of antipsychotics in children and adolescents remains controversial.
Therapeutics Initiative (University of British Columbia)
core
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
, 1995 Therapeutics Letter 6 considers the optimal use of nitrates for the medical management of ischemic heart disease. Conclusions: There is increasing evidence that beta-blockers are the drug of first choice in the management of angina.
Therapeutics Initiative (University of British Columbia)
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source