Results 131 to 140 of about 1,055,467 (319)
Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets
MedCommThe substantial loss of cardiomyocytes resulting from myocardial infarction leads to pathological remodeling of the heart and the onset of heart failure.
Mingchuan Liu +9 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Interplay of Aging and Cancer: Mechanisms, Implications, and Therapeutic Strategies
MedComm – OncologyAging is a complex biological process that significantly influences human health, including susceptibility to cancer. Although aging and cancer are distinct phenomena, they intersect through shared molecular mechanisms such as genomic instability ...
Liangce Wang +4 more
doaj +1 more source
, 2018 Therapeutics Letter 115 examines cannabinoids for chronic pain. Conclusions: Health care providers need to be knowledgeable and non-judgmental when informing patients about cannabinoids.
Therapeutics Initiative (University of British Columbia)
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
, 2017 Therapeutics Letter 104 reviews the evidence on medicine reviews as a means of improving health. Conclusions: Medication Review is an unproven intervention that has the potential to improve health outcomes and therefore needs to be evaluated in ...
Therapeutics Initiative (University of British Columbia)
core
Therapeutic atmospheres. The aesthetics of therapeutic spaces
Lebenswelt. Aesthetics and philosophy of experience.This article explores the spatial dimensions of selfhood and the pathic felt-bodily resonance, emphasizing their role in understanding the connection between health and the environment. Adopting a phenomenological perspective, it provides an overview of the relationship between embodiment, spatiality, and affectivity and their alterations in mental ...
openaire +3 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source