Results 21 to 30 of about 1,412,582 (334)

Immunopathogenesis of rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that
Ahmed, Ai, Ai, Anzilotti, Arend, Astorri, Benham, Bombardieri, Bottini, Bottini, Byng-Maddick, Catrina, Catrina, Charles-Schoeman, Christophorou, Corsiero, Croft, de Aquino, de Hair, Deane, Dennis, Diarra, Ekwall, El-Gabalawy, Ferreira, Filer, Firestein, Firestein, Firestein, Firestein, Firestein, Fonseca, Franz, Gary S. Firestein, Genovese, Hammaker, Harre, Hill, Horiuchi, Huber, Iain B. McInnes, Joosten, Juarez, Kaminsky, Karouzakis, Kelly, Kiener, Kim, Kinslow, Kirschmann, Klarenbeek, Konig, Konig, Krishnadas, Krishnamurthy, Källberg, Langley, Law, Lee, Lefèvre, Linn-Rasker, Liu, Lubberts, Lundström, Makrygiannakis, Matsumoto, McInnes, McInnes, McInnes, McInnes, McKellar, Miossec, Mydel, Müller-Ladner, Nakamachi, Nakano, Nakano, Nam, Okada, Pap, Perlman, Pitzalis, Randen, Rawlings, Raychaudhuri, Raza, Reynisdottir, Reynisdottir, Robertson, Rodríguez-Carrio, Rombouts, Rossetti, Scally, Scher, Schiff, Shi, Shi, Smolen, Smolen, Snir, Sokolove, Stanczyk, Suzuki, Tan, Tran, Tsaprouni, van Beers, van der Helm-van Mil, Vassallo, Wang, Wegner, Weyand, Yamamoto, Yang, Zhang, Zvaifler   +115 more
core   +1 more source

Cell Therapy for Type 1 Diabetes [PDF]

, 2014
Acknowledgements The work described in this review was supported by a grant from the MRC. K.R.M. is supported by a fellowship from the Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust.Peer reviewedPublisher ...
Docherty, H. M., Docherty, K., Lima, M. J., Muir, K. R.   +3 more
core   +1 more source

Therapeutic Trust [PDF]

Philosophical Psychology, 2022
Abstract This chapter extends the telic normativity framework to therapeutic trust and characterizes its nature and its constitutive norms. Central to the view advanced is a distinction between two kinds of therapeutic trust—default therapeutic trust and overriding therapeutic trust—each of which derives from a distinct kind of trusting ...
openaire   +1 more source

Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases

Biomolecules, 2020
Neurodegenerative diseases (NDs) are characterized by the accumulation of misfolded proteins. The hallmarks of protein aggregation in NDs proceed with impairment in the mitochondrial function, besides causing an enhancement in endoplasmic reticulum (ER ...
Mujtaba Aamir Bhat, Khurshid Ahmad, Mohd Sajjad Ahmad Khan, Mudasir Ahmad Bhat, Ahmad Almatroudi, Safikur Rahman, Arif Tasleem Jan   +6 more
doaj   +1 more source

Novel Therapeutics: A Nemesis for Biofilm-forming Mycobacterium spp.

Journal of Pure and Applied Microbiology, 2023
Tuberculosis (TB) is a contagious disease that is a significant cause of illness worldwide and has been declared one of the top ten causes of mortality across the world.
Niharika Pandey, Firoz Ahmad, Kratika Singh, Pranshu Pandey, Rolee Sharma   +4 more
doaj   +1 more source

Interconnections between the Oral and Gut Microbiomes: Reversal of Microbial Dysbiosis and the Balance between Systemic Health and Disease

Microorganisms, 2021
The human microbiota represents a complex array of microbial species that influence the balance between the health and pathology of their surrounding environment.
Brandon Khor, Michael Snow, Elisa Herrman, Nicholas Ray, Kunal Mansukhani, Karan A. Patel, Nasser Said-Al-Naief, Tom Maier, Curtis A. Machida   +8 more
doaj   +1 more source

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling [PDF]

, 2011
The failure of biology to identify the molecular causes of disease has led to disappointment in the rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes ...
Christine Suver, David Henderson, Jonathan Derry, Jonathan Derry, Jonathan Izant, Lara Mangravite, Matt Furia, Michael Kellen, Solveig Sieberts, Stephen Friend, Xavier Schildwachter   +10 more
core   +2 more sources

Navigating regulatory and analytical challenges in live biotherapeutic product development and manufacturing

Frontiers in Microbiomes
The recent FDA approvals of Rebyota™ and Vowst™ represent landmark milestones within the burgeoning field of live microbiota-based products. Future microbiota-based treatment approaches also hold significant promise for treating patients with a myriad of
Microbiome Therapeutics Innovation Group, Dana Barberio   +1 more
doaj   +1 more source

Hypoxia-Driven Immune Escape in the Tumor Microenvironment

Cells, 2020
The tumor microenvironment is a complex ecosystem comprised of many different cell types, abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with which tumors grow leads to increased oxygen consumption and, in turn ...
Alyssa Vito, Nader El-Sayes, Karen Mossman   +2 more
doaj   +1 more source

Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19)

Pathogens, 2020
The ongoing episode of coronavirus disease 19 (COVID-19) has imposed a serious threat to global health and the world economy. The disease has rapidly acquired a pandemic status affecting almost all populated areas of the planet.
Muhammad Shahid Nadeem, Mazin A. Zamzami, Hani Choudhry, Bibi Nazia Murtaza, Imran Kazmi, Habib Ahmad, Abdul Rauf Shakoori   +6 more
doaj   +1 more source