Results 21 to 30 of about 1,429,081 (399)
Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022 The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Binghan Zhou +6 more
semanticscholar +1 more source
A spoonful of sugar: the application of glycopolymers in therapeutics [PDF]
, 2011 Glycopolymers, synthetic polymers displaying carbohydrate moieties, have been linked to many potential applications at the biology–chemistry interface. One area that holds particular promise is the employment of glycopolymers as vehicles for therapeutics
Cameron, Neil R., Spain, Sebastian G.
core +2 more sources
Clinical Pharmacology & Therapeutics: Past, Present, and Future. [PDF]
, 2017 Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline ...
Terzic, Andre, Waldman, Scott A.
core +2 more sources
OncoImmunology, 2021 Co-stimulatory 4–1BB receptors on tumor-infiltrating T cells are a compelling target for overcoming resistance to immune checkpoint inhibitors, but initial clinical studies of 4–1BB agonist mAbs were accompanied by liver toxicity. We sought to engineer a
Stefan Warmuth +23 more
doaj +1 more source
Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders [PDF]
, 2016 The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases ...
Aggarwal, M. +5 more
core +1 more source
Exosomes in Age-Related Cognitive Decline: Mechanistic Insights and Improving Outcomes
Frontiers in Aging Neuroscience, 2022 Aging is the most prominent risk factor for cognitive decline, yet behavioral symptomology and underlying neurobiology can vary between individuals. Certain individuals exhibit significant age-related cognitive impairments, while others maintain intact ...
Michael R. Duggan +4 more
doaj +1 more source
mRNA-based therapeutics: powerful and versatile tools to combat diseases
Signal Transduction and Targeted Therapy, 2022 The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the production of almost any functional protein/peptide in the ...
Shugang Qin +10 more
semanticscholar +1 more source
CD98hc is a target for brain delivery of biotherapeutics
Nature Communications, 2023 Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3A2) of ...
Kylie S. Chew +49 more
doaj +1 more source
Pregabalin: a range of misuse-related unanswered questions [PDF]
, 2019 © 2019 The Authors.
Chiappini, Stephania, Schifano, Fabrizio
core +1 more source
Metal-Organic Frameworks and Their Composites Towards Biomedical Applications
Frontiers in Molecular Biosciences, 2021 Owing to their unique features, including high cargo loading, biodegradability, and tailorability, metal–organic frameworks (MOFs) and their composites have attracted increasing attention in various fields.
Yana Ma +7 more
doaj +1 more source