Results 51 to 60 of about 1,594,004 (375)
Hypoxia-Driven Immune Escape in the Tumor Microenvironment
Cells, 2020 The tumor microenvironment is a complex ecosystem comprised of many different cell types, abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with which tumors grow leads to increased oxygen consumption and, in turn ...
Alyssa Vito +2 more
doaj +1 more source
Pancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]
, 2014 Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.
Andrew Eugene Hendifar +8 more
core +2 more sources
Trials and Tribulations of MicroRNA Therapeutics
International Journal of Molecular SciencesThe discovery of the link between microRNAs (miRNAs) and a myriad of human diseases, particularly various cancer types, has generated significant interest in exploring their potential as a novel class of drugs.
A. Seyhan
semanticscholar +1 more source
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.
New England Journal of Medicine, 2019 BACKGROUND Although several experimental therapeutics for Ebola virus disease (EVD) have been developed, the safety and efficacy of the most promising therapies need to be assessed in the context of a randomized, controlled trial.
S. Mulangu +50 more
semanticscholar +1 more source
Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19)
Pathogens, 2020 The ongoing episode of coronavirus disease 19 (COVID-19) has imposed a serious threat to global health and the world economy. The disease has rapidly acquired a pandemic status affecting almost all populated areas of the planet.
Muhammad Shahid Nadeem +6 more
doaj +1 more source
Pharmaceutics, 2022 Dengue, West Nile and Zika viruses are vector-borne flaviviruses responsible for numerous disease outbreaks in both Hemispheres. Despite relatively low mortality, infection may lead to potentially severe situations such as (depending on the virus ...
Ivo C. Martins +2 more
doaj +1 more source
Image-guided therapy using maghemite-MOF nanovectors [PDF]
, 2017 Advances in nanotechnology offer the possibility of tailored delivery of therapeutics with real-time imaging of disease. In this issue of Chem, Steunou and co-workers amalgamate the powerful MRI properties of ultra-small paramagnetic iron oxides with the
Abánades Lázaro, Isabel +1 more
core +1 more source
Obesity: Epidemiology, Pathophysiology, and Therapeutics
Frontiers in Endocrinology, 2021 Obesity is a complex multifactorial disease that accumulated excess body fat leads to negative effects on health. Obesity continues to accelerate resulting in an unprecedented epidemic that shows no significant signs of slowing down any time soon. Raised
Xihua Lin, Hong Li
semanticscholar +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Exploring the potential of transethosomes in therapeutic delivery: A comprehensive review
MedComm – Biomaterials and Applications, 2023 The growing need for innovative drug delivery systems has led to extensive research to address the limitations associated with conventional dosage forms.
Pavani Chowdary +2 more
doaj +1 more source