Results 61 to 70 of about 1,055,467 (319)
Lichenoid dysplasia treated by apremilast - report of two cases and review of literature
Journal of Family Medicine and Primary CareLichenoid dysplasia (LD) is a distinct clinicopathologic condition characterized by bilateral or unilateral oral lesions with a lichenoid pattern and atypical cells, giving it a higher risk for malignant transformation. Unlike oral lichen planus (OLP) or
Shiladitya Sil +3 more
doaj +1 more source
, 1995 Therapeutics Letter 9 reviews the recommendations published by The Therapeutics Initiative in our first year, including some updated information based on feedback which we have received from readers of the Therapeutics Letter.Medicine, Faculty ...
Therapeutics Initiative (University of British Columbia)
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Immune cells in Alzheimer’s disease: insights into pathogenesis and potential therapeutic targets
Medical ReviewAlzheimer’s disease (AD) is a chronic neurodegenerative disorder for which there are currently no effective treatment options. Increasing evidence suggests that AD is a systemic disease closely associated with the immune system, not merely a central ...
Fu Xiaofeng +5 more
doaj +1 more source
, 2019 Therapeutics Letter 121 is the first of two issues celebrating 25 years of The Therapeutics Initiative by highlighting key conclusions from the 120 issues of the Therapeutics Letter that have been published to date.Medicine, Faculty ofAnesthesiology ...
Therapeutics Initiative (University of British Columbia)
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
MembranesThe transition of peptides or proteins along a misfolding continuum from soluble functional states to pathological aggregates, to ultimately deposit as amyloid fibrils, is a process that underlies an expanding group of human diseases—collectively known ...
Raina Marie Seychell +2 more
doaj +1 more source
, 2007 Therapeutics Letter 64 provides results of the Therapeutics Initiative's (TI) third readership survey to evaluate perceptions of TI educational activities.Medicine, Faculty ofAnesthesiology, Pharmacology and Therapeutics, Department ofReviewedThe UBC TI ...
Therapeutics Initiative (University of British Columbia)
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Health Technology AssessmentBackground Cystic fibrosis is a life-limiting genetic condition that affects over 9000 people in England. Cystic fibrosis is usually diagnosed through newborn screening and causes symptoms throughout the body, including the lungs and digestive system ...
Steven J Edwards +7 more
doaj +1 more source