Results 51 to 60 of about 1,055,467 (319)
Scientific ReportsMultiple sclerosis (MS) is a chronic neurological disease characterized by inflammatory demyelination that disrupts neuronal transmission resulting in neurodegeneration progressive disability.
Michael M. Poon +13 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC
Communications ChemistryTargeted Protein Degradation (TPD) technology, in the form of CRBN-modulating molecular glues, offers numerous unprecedented therapeutic benefits as evidenced by the success of approved high-value immunomodulatory imide drugs (IMiDs) such as lenalidomide
Przemysław Glaza +28 more
doaj +1 more source
, 2019 Therapeutics Letter 124 provides results of the Therapeutics Initiative's fifth readership survey to evaluate perceptions of our academic unit and the impact of Therapeutics Initiative learning events.Medicine, Faculty ofAnesthesiology, Pharmacology and ...
Therapeutics Initiative (University of British Columbia)
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, 2020 Therapeutics Letter 127 discusses personal prescribing portraits as an innovative method for community-based physicians to monitor and evaluate the appropriateness of their prescribing practices.Medicine, Faculty ofAnesthesiology, Pharmacology and ...
Therapeutics Initiative (University of British Columbia)
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Gut microbiota: emerging biomarkers and potential therapeutics for premature ovarian failure
Frontiers in MicrobiologyPremature ovarian failure is a prevalent gynecological endocrine disorder with an increasing incidence rate each year, impacting women’s physical and mental health.
Zongyu Liu +10 more
doaj +1 more source
, 2019 Therapeutics Letter 122 is the second of two issues celebrating 25 years of The Therapeutics Initiative by highlighting key conclusions from the 120 issues of the Therapeutics Letter that have been published to date.Medicine, Faculty ofAnesthesiology ...
Therapeutics Initiative (University of British Columbia)
core
, 2022 Therapeutics Letter 136 examines conflicts of interest in primary care and the pharmaceutical industry. Conclusions: Industry sponsorship of clinical trials can lead to biased conclusions, including exaggerated claims of efficacy and underestimation of ...
Therapeutics Initiative (University of British Columbia)
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source