Results 81 to 90 of about 1,055,467 (319)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 1999 Therapeutics Letter 31 considers the importance of making unpublished clinical trial data available in the context of the approval of celecoxib. Conclusions: In this case, the only information available to help the clinician decide whether to prescribe ...
Therapeutics Initiative (University of British Columbia)
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2001 Therapeutics Letter 39 adds new evidence to information previously published about NSAIDs in Therapeutics Letters 4 and Letter 17. It also responds to our commitment in Therapeutics Letter 31 to report on celecoxib when published trials became available.
Therapeutics Initiative (University of British Columbia)
core
, 2021 Therapeutics Letter 131 considers the harms and potential benefits of tramadol. Conclusions: Compared with acetaminophen, NSAIDs or other opioids, tramadol has no therapeutic advantage but some disadvantages.
Therapeutics Initiative (University of British Columbia)
core
EXPERIMENTAL THERAPEUTICS [PDF]
Journal of the American Medical Association, 1912 n ...
openaire +2 more sources
Journal of the Royal College of Physicians of London, 1995 A joint conference on therapeutics with the Faculty of Pharmaceutical Medicine was held at the Royal College of Physicians on 28 June 1995, organised by Professor M C L'E Orme. A wide variety of topics was covered ranging from management of acute poisoning to the treatment of myocardial infarction, as well as the teaching of therapeutics in the new ...
M, Pirmohamed, U, Martin
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Intermittent Fasting Targets Osteocyte Neuropeptide Y to Relieve Osteoarthritis
Advanced ScienceOsteoarthritis is a highly prevalent progressive joint disease that still requires an optimal therapeutic approach. Intermittent fasting is an attractive dieting strategy for improving health.
Yu‐Xuan Qian +20 more
doaj +1 more source
The role of the HIV-1 gut reservoir in driving early cardiovascular events in people living with HIV
Frontiers in Drug DiscoveryPeople with HIV (PWH), even when well-controlled on antiretroviral therapy (ART), are at an increased risk for cardiovascular disease (CVD) and CVD events including sudden cardiac death and acute myocardial infarction (MI).
Keri Kramer +14 more
doaj +1 more source