Results 91 to 100 of about 1,055,467 (319)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2012 Therapeutics Letter 85 presents selected direct quotes published in recent issues of Prescrire International. Topics covered include aliskiren, drugs for Alzheimer's disease, escitalopram, gabapentin, pregabalin, migraine headaches, and varenicline ...
Therapeutics Initiative (University of British Columbia)
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Minimising inhaled corticosteroids for COPD
African Journal of Primary Health Care & Family MedicineThis Therapeutic Letter considers the evidence for inhaled corticosteroids (ICS) as a treatment for Chronic Obstructive Pulmonary Disease (COPD). Drug therapy aims to alleviate symptoms, enhance functional capacity and prevent exacerbations, but has not ...
Benji Heran +2 more
doaj +1 more source
, 2006 Therapeutics Letter 60 presents selected summaries published by La Revue Prescrire, an independent French drug bulletin. Drugs discussed include alendronate, risedronate, topiramate, tiotropium, and neuroleptics.Medicine, Faculty ofAnesthesiology ...
Therapeutics Initiative (University of British Columbia)
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 1995 Therapeutics Letter 5 discusses the Ontario Anti-infective Review Panel's Anti-infective Guidelines for Community-acquired Infections. The guidelines were designed to be an educational tool to help promote appropriate use of anti-infective medications ...
Therapeutics Initiative (University of British Columbia)
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
BiomedicinesParkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J. Rademacher +2 more
doaj +1 more source
, 2011 Therapeutics Letter 82 highlights five Cochrane systematic reviews about hypertension, which provide clear clinical evidence to direct patient care. Interventions reviewed include relaxation therapies, beta blockers, calcium channel blockers, first-line ...
Therapeutics Initiative (University of British Columbia)
core