Results 111 to 120 of about 4,145,262 (262)

A hybrid multiagent approach for global trajectory optimization [PDF]

, 2008
In this paper we consider a global optimization method for space trajectory design problems. The method, which actually aims at finding not only the global minimizer but a whole set of low-lying local minimizers(corresponding to a set of different design
Vasile, M., Vasile, Massimiliano, Locateli, M., VASILE M., Locatelli, Marco   +4 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Flux Weakening Strategy Optimization for Five-Phase PM Machine with Concentrated Windings [PDF]

, 2012
The paper applies an Efficient Global Optimization method (EGO) to improve the efficiency, in flux weakening region, of a given 5-phase Permanent Magnet (PM) machine. An optimal control for the four independent currents is thus defined.
JILIN, Gong, ASLAN, Bassel, SEMAIL, Eric, GILLON, Frédéric   +3 more
core  

Recreation therapy in the time of Covid-19, a multi-faceted rapid knowledge synthesis on the implications and opportunities of telehealth for recreation therapy practice

, 2021
The COVID-19 pandemic has resulted in many challenges for people accessing basic Human Rights in life and leisure. With repeated lockdowns and many individuals choosing social isolation to reduce the risk of infection, this has left a large proportion of
Alford, Stewart (R19505), Grashorn, Josh, Peel, Nicole (R18401)   +2 more
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

EVIDENCIA DEL TRATAMIENTO DE OXIGENACIÓN HIPERBÁRICA EN LA OPTIMIZACIÓN DE COSTOS SANITARIOS

Revistas Argentina de Medicina, 2019
El tratamiento de oxigenación hiperbárica (TOHB) acelera los tiempos de cicatrización de los distintos tipos de heridas, entre ellas el pie diabético. Igualmente, favorece la rehabilitación neurológica y reduce las complicaciones postquirúrgicas.
Mónica del Carmen Jorge, Laura Ríos, Oscar Merbilhaa, Mercedes Portas   +3 more
doaj   +2 more sources

Is CRT Optimization Obsolete? A Referral Center’s Experience

Reviews in Cardiovascular Medicine
Background: Cardiac resynchronization therapy (CRT) is a well-established therapy for patients with heart failure (HF). However, 30% of HF patients do not show any improvement in clinical status after CRT implantation.
Shmaila Saleem-Talib, Mirjam D. Duineveld, Jurjan C. Schipper, Arnaud D. Hauer, Hemanth Ramanna, Natasja M.S. de Groot, Michael G. Scheffer   +6 more
doaj   +1 more source

Taking a long look at Art: Reflections on the context of production and consumption of art in Art Therapy [PDF]

, 2014
This paper draws on experiences of looking at art to consider the influence of social context on the production and consumption of art in art therapy. I draw on art historical discourses to explore the experience and relate this to looking at art in art ...
Gilroy, Andrea
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source