Results 41 to 50 of about 73,080 (268)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Prediction and analysis of thermal aging behavior of magnetorheological grease
Materials Research Express, 2021 Magnetorheological grease (MRG) is a new type of field-response intelligent material with controllable performance and excellent settlement stability, which is feasible to replace traditional materials.
Guangxin Yang +4 more
doaj +1 more source
Thermal Aging of Twaron Fibers [PDF]
High Performance Polymers, 2003 The residual effects of thermal aging on Twaron fibers have been studied using X-ray diffraction, weight analysis, scanning electron microscopy and tensile testing. X-ray data from isothermally aged fibers indicate the introduction of changes at the level of the crystal lattice, which include reduction in crystallinity, variations in 20 values, half ...
Anjana Jain, Kalyani Vijayan
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Advanced ScienceThe significant role of the cathodic binder in modulating mass transport within the catalyst layer (CL) of fuel cells is essential for optimizing cell performance.
Min Li +11 more
doaj +1 more source
IEEE Access, 2020 This article presents the influence of thermal aging on space charge accumulation and dissipation of cross-linked polyethylene (XLPE) with different cross-linking agent contents. In this article, dicumyl peroxide (DCP) and low-density polyethylene (LDPE)
Shuchao Wang +6 more
doaj +1 more source
Experimental study on mechanical property degradation of thermal aging laminated rubber bearing
Case Studies in Construction Materials, 2023 Laminated Rubber Bearing (LRB) plays a significant role in recent bridge-supporting systems and its characteristics are mainly contributed by their nonlinear properties. However, LRB performance deteriorates during aging.
Zhongying He +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source