Results 51 to 60 of about 9,648,016 (296)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Test Submission

open access: yes, 2021
This is a sample submission generated by Vireo to test the repository deposit features.Test ...
Submitter, Test
core  

基于热网络法的汽车变速器热平衡分析

open access: yesJixie chuandong, 2014
In order to solve the high temperature problem resulting from powerloss of automobile transmission when the transmission is working,the heat balance of the transmission is analyzed.The heat balance equations of the transmission are established by using ...
周廷美, 何庆, 周浩, 巫绍宁
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Verfahrensdokumentation für ABC-D: Activities-Specific Balance Confidence-Skala

open access: yes, 2011
Bei der ABC-D handelt es sich um ein Selbstbeurteilungsverfahren zur Erfassung der sturzassoziierten Selbstwirksamkeit. Er enthält 16 Items, aus denen die zwei Subskalen (1) Sturzbezogene Selbstwirksamkeit bei einfachen Aktivitäten (7 Items) sowie (2 ...
Schott, N.
core   +1 more source

Protective Ceramic Coatings for Solid Oxide Fuel Cell (SOFC) Balance-of-Plant Components

open access: yesAdvances in Materials Science and Engineering, 2018
Solid oxide fuel cells (SOFCs) have the potential to meet the growing need for electrical power generation if the cost per megawatt can be further reduced. Currently, SOFC stacks are replaced too frequently to be cost competitive.
Raymond L. Winter   +4 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

Thermal analysis of the high sensitivity terahertz detection module under different operating modes of the evaporator

open access: yesResults in Engineering
This paper presents a systematic thermal design of the terahertz detection module and analyzes the evaporator's operational modes. A comparative thermal analysis was performed across three modes, with the most extreme mode selected for thermal balance ...
Yantang Hua   +7 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

open access: yesFEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli   +3 more
wiley   +1 more source

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