Results 61 to 70 of about 749,354 (336)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Laboratory Investigation of Heterogeneous Metamorphic Rocks and Their Spatial Distribution of Thermal Conductivity

open access: yesEnergies
Assessing the variation in the thermal conductivity of heterogeneous rock materials can be critical when upscaling models to simulate geothermal system operation, especially for petrothermal systems, where conduction dominates over convection. This study’
Miora Mirah Rajaobelison   +3 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

open access: yesFEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq   +3 more
wiley   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

open access: yesFEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Effect of aggregation on thermal conduction in ternary molten salt-based nanofluids: insights from a multiscale coupled MD–LBM method

open access: yesEnergy Storage and Saving
Molten salts serve as primary heat transfer and storage media in thermal energy storage systems. Adding nanoparticles to molten salt to create nanofluids is known to significantly improve the thermal conductivity of the molten salts.
Zhe Yang   +7 more
doaj   +1 more source

Research on thermal conductivity of HGMs at vacuum in room temperature

open access: yesAIP Advances, 2018
Hollow glass microspheres (HGMs) can be used as thermal insulation materials owing to its hollow structure which brings excellent thermal insulation property and low density.
Ping Wang   +4 more
doaj   +1 more source

Lattice thermal conductivity of disordered NiPd and NiPt alloys

open access: yes, 2006
Numerical calculations of lattice thermal conductivity are reported for the binary alloys NiPd and NiPt. The present work is a continuation of an earlier paper by us [PRB, 72, 214207 (2005)]which had developed a theoretical framework for the calculation ...
Abhijit Mookerjee   +9 more
core   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

open access: yesFEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima   +4 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

open access: yesFEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori   +8 more
wiley   +1 more source

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