Results 41 to 50 of about 349,666 (265)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Isopods failed to acclimate their thermal sensitivity of locomotor performance during predictable or stochastic cooling. [PDF]

PLoS ONE, 2011
Most organisms experience environments that vary continuously over time, yet researchers generally study phenotypic responses to abrupt and sustained changes in environmental conditions.
Matthew S Schuler, Brandon S Cooper, Jonathan J Storm, Michael W Sears, Michael J Angilletta   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effects of Constant versus Fluctuating Temperatures on Fitness Indicators of the Aphid Dysaphis plantaginea and the Parasitoid Aphidius matricariae

Insects, 2021
Testing fluctuating rather than constant temperatures is likely to produce more realistic datasets, as they are ecologically more similar to what arthropods experience in nature. In this study, we evaluated the impact of three constant thermal regimes (7,
Kévin Tougeron, Louise Ferrais, Marie-Eve Renard, Thierry Hance   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Non-homogeneity effect on the vibration of the rectangular visco-elastic plate subjected to the linear temperature effect with quadratic thickness variation in both directions

Acta Polytechnica
The present work investigates the effect of non-homogeneity on the vibration of a rectangular visco-elastic plate. The plate is subjected to linear temperature variation in the x-direction with quadratic thickness variation in both directions.
Sudhanshu Aggarwal
doaj   +1 more source

Studying thermal conductivity of magnetic nanofluids in constant magnetic field

MATEC Web of Conferences, 2017
The thermal conductivity of magnetic nanofluids in a constant magnetic field is investigated. The concentration dependence of the thermal conductivity coefficient of magnetic fluids based on water and iron oxide nanoparticles Fe3O4 in a constant magnetic
Pryazhnikov Maxim, Minakov Andrey, Guzei Dmitriy, Zhigarev Vladimir   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Evaluation of Linear and Non-Linear Models to Describe Temperature-Dependent Development of Scopula subpunctaria (Lepidoptera: Geometridae) and Its Stage Transition Models

Agronomy
Scopula subpunctaria (Herrich-Schaeffer), is a significant insect pest affecting tea plantations in China; however, its thermal developmental characteristics remain inadequately understood.
Shubao Geng, Junchuan Song, Heli Hou, Pei Zhang, Fangmei Zhang, Li Qiao, Xiaoguang Liu, Chuleui Jung   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source