Results 41 to 50 of about 26,517,134 (293)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Active Management of Distributed Generation based on Component Thermal Properties [PDF]

, 2010
Power flows within distribution networks are expected to become increasingly congested with the proliferation of distributed generation (DG) from renewable energy resources.
JUPE, SAMUEL,CHARLES,EDWARD, Jupe, Samuel Charles Edward   +1 more
core  

Online thermal control methods for multiprocessor systems [PDF]

ACM Transactions on Design Automation of Electronic Systems, 2013
With technological advances, the number of cores integrated on a chip is increasing. This in turn is leading to thermal constraints and thermal design challenges. Temperature gradients and hotspots not only affect the performance of the system but also lead to unreliable circuit operation and affect the lifetime of the chip.
Zanini, Francesco, Atienza Alonso, David, Jones, Colin, Benini, Luca, De Micheli, Giovanni   +4 more
openaire   +5 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dynamic Analysis and Intelligent Control Strategy for the Internal Thermal Control Fluid Loop of Scientific Experimental Racks in Space Stations

Entropy, 2020
Scientific experimental racks are an indispensable supporter in space stations for experiments with regard to meeting different temperature and humidity requirements.
Ben-Yuan Cai, Hui-Yi Wei, Yun-Ze Li, Yuan-Yuan Lou, Tong Li   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Impedance investigation of the surface film formed on aluminum alloy exposed to nuclear reactor emergency core coolant

Nuclear Engineering and Technology, 2023
A method was proposed for in-situ evaluating the thickness and resistivity of the oxide/hydroxide film formed on the surface of aluminum alloy exposed to sump water formed in the containment after a loss-of-coolant accident.
Junlin Huang, Derek Lister, Xiaoliang Zhu, Shunsuke Uchida, Qinglan Xu   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Investigation of thermal conditions of nanosatellite optoelectronic telescopic module for different modes of operation

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2019
The problem of studying thermal conditions of the optoelectronic telescopic module of a nanosatellite under the influence of operating conditions is considered. To maintain optimal thermal conditions of the telescopic lens, a thermal control system based
S. V. Tsaplin, S. A. Bolychev
doaj   +1 more source