Results 61 to 70 of about 26,517,134 (293)

Investigation of the thermal regime of microsatellite optoelectronic telescopic complex under operating conditions

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017
An optoelectronic telescopic lens-type complex is proposed for the purpose of creating a domestic constellation of Earth remote sensing satellites with the ability of timely obtaining of the imagery on-demand.
S. V. Tsaplin, S. A. Bolychev
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Operational Engineering of the COLUMBUS Thermal and Environmental Control System: Achievements, Optimizations [PDF]

, 2010
After commissioning of the European space-borne science laboratory Columbus, many operational products had to be improved and adapted to changing environmental conditions and new operational experiences.
Porth, N., Kohlhase, A. O., Doye, J.
core  

Research progress in nanofluids with graphene addition

Cailiao gongcheng, 2020
Lubrication and cooling are two important issues in the current industrial field. The former is of great significance to the energy consumption caused by friction, which is directly related to the service reliability and life of the components in the ...
BAI Ming-jie, LIU Jin-long, QI Zhi-na, HE Jiang, WEI Jun-jun, MIAO Jian-yin, LI Cheng-ming   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Experimental Study on Vacuum Thermal Performance of RTPV

Yuanzineng kexue jishu, 2023
In the 250 Wt RTPV (radioisotope thermophoto-voltaic) system, the heat source operates at a temperature above 1 000 ℃, which requires a long term stable thermal insulation devices. In this paper, three types of non-sealed high temperature MLI (multilayer
SU Sheng;SHAO Jianxiong;QIU Jiawen;CHEN Yang;MA Juyin;TIAN Dai;MA Bin;HAN Chengzhi
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adaptive Variable Universe Fuzzy Droop Control Based on a Novel Multi-Strategy Harris Hawk Optimization Algorithm for a Direct Current Microgrid with Hybrid Energy Storage

Energies
In the off-grid photovoltaic DC microgrid, traditional droop control encounters challenges in effectively adjusting the droop coefficient in response to varying power fluctuation frequencies, which can be influenced by factors such as line impedance ...
Chen Wang, Shangbin Jiao, Youmin Zhang, Xiaohui Wang, Yujun Li   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source