Results 51 to 60 of about 27,107 (213)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Case Studies in Thermal EngineeringThis paper presents an evaluation of the thermal performance of a circular tube with louvered V-winglet inserts (LVWs) under turbulent flow conditions.
Anuwat Saenpong +3 more
doaj +1 more source
Design Process of a Triple Redundant Fault Tolerant PMA SynRM
IEEE Access, 2019 Fault tolerant machine drives are being favored by safety-critical applications. However, the machine needs to be carefully designed since it is required to achieve high performance in healthy condition as well as good fault tolerance for various faults.
Bo Wang, Jiapeng Hu, Wei Hua
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Age‐related circulatory responses to whole body cooling: observations by heart rate variability
Finnish Journal of eHealth and eWelfare, 2015 The purpose was to study potential age ‐ related changes in the circulatory system via heart rate variability (HRV) by gradually lowering ambient temperature (0.2°C/min) from thermoneutral (32 C°) towards cold (18 C°).
Jarmo Alametsä +7 more
doaj
Results in Control and OptimizationEach server in data centers is equipped with multiple fans and heat-generating components. Factors such as fans speed, layout of components, and loading scenarios, will influence the airflow and thermal flow fields within a server.
Chun-Wei Lan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source