Results 41 to 50 of about 336,265 (266)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Bi-LSTM, GRU and 1D-CNN models for short-term photovoltaic panel efficiency forecasting case amorphous silicon grid-connected PV system

Results in Engineering
Photovoltaic (PV) panels stand as a prominent solution to meet the world's growing energy demands, due to their resistance to hard climate conditions, low-cost maintenance, and long lifetime. Nonetheless, the integration of PV power into electrical grids
Abdellatif Ait Mansour, Amine Tilioua, Mohammed Touzani   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Energy Demand Response in a Food-Processing Plant: A Deep Reinforcement Learning Approach

Energies
The food industry faces significant challenges in managing operational costs due to its high energy intensity and rising energy prices. Industrial food-processing facilities, with substantial thermal capacities and large demands for cooling and heating ...
Philipp Wohlgenannt, Sebastian Hegenbart, Elias Eder, Mohan Kolhe, Peter Kepplinger   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Optimization and Application of Ammonia Spraying Device Using Dynamic Matrix Control with Variable Parameters Based on Feed-Forward Loop

Zhongguo dianli, 2019
Facing the challenges of the controls in the selective catalytic reduction (SCR) flue gas denitration system of thermal power units, such as long duration of time delay, high inertia and strong nonlinearities, typical PID regulator-based ammonia spraying
Xin XUN, Kai SHENG, Xiangyu CHEN, Jijun DENG   +3 more
doaj   +1 more source

IMPROVING THERMAL EFFICIENCY OF PHOTOVOLTAIC THERMAL SYSTEMS

AURUM Journal of Engineering Systems and Architecture
The research presents the daily and monthly global solar radiation on a horizontal surface in Iraq and applies it to the PVT water system. The research contributes in two ways: first, it models a novel copper pipe system that improves thermal efficiency in an actual environment, and second, it investigates the hourly and daily intensity of solar ...
Mohammed Abbas Fadhil Alkhafaji, İbrahim Koç   +1 more
openaire   +2 more sources

Energy efficiency by thermal spraying [PDF]

WIT Transactions on Ecology and the Environment, 2014
Machines used by the basic industries of Russia (metallurgy, oil-gas processing and power engineering) are characterized by high metal consumption, which in turn lead to high energy consumption. Their service lives increase and their worn parts are restored by means of low-cost materials for restoration.
Korobov, Y., Shalimov, M.
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source