Results 61 to 70 of about 1,369,127 (302)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Optimization and Application of Ammonia Spraying Device Using Dynamic Matrix Control with Variable Parameters Based on Feed-Forward Loop

Zhongguo dianli, 2019
Facing the challenges of the controls in the selective catalytic reduction (SCR) flue gas denitration system of thermal power units, such as long duration of time delay, high inertia and strong nonlinearities, typical PID regulator-based ammonia spraying
Xin XUN, Kai SHENG, Xiangyu CHEN, Jijun DENG   +3 more
doaj   +1 more source

Battery cell thermal-conductive coating increases efficiency [PDF]

, 1973
Thin coating of high-temperature epoxy resin provides necessary electrical insulation, as well as good thermal conductivity between battery cells. Insulation increases efficiency of nickel-cadmium battery, as it would any multicell battery assembly in ...
Doyle, H. M.
core   +1 more source

Toward phonon-boundary engineering in nanoporous materials [PDF]

, 2014
Tuning thermal transport in nanostructured materials is a powerful approach to develop high-efficiency thermoelectric materials. Using a recently developed approach based on the phonon mean free path dependent Boltzmann transport equation, we compute the
Grossman, Jeffrey C., Romano, Giuseppe
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Engineering spin-orbit torque in Co/Pt multilayers with perpendicular magnetic anisotropy

, 2015
To address thermal stability issues for spintronic devices with a reduced size, we investigate spin-orbit torque in Co/Pt multilayers with strong perpendicular magnetic anisotropy.
Huang, Kuo-Feng, Lai, Chih-Huang, Lin, Hsiu-Hau, Wang, Ding-Shuo   +3 more
core   +1 more source

Optimal Prandtl number for heat transfer in rotating Rayleigh-Benard convection [PDF]

, 2009
Numerical data for the heat transfer as a function of the Prandtl (Pr) and Rossby (Ro) numbers in turbulent rotating Rayleigh-Benard convection are presented for Rayleigh number Ra = 10^8.
Detlef Lohse, Herman J H Clercx, Kunnen R P J, Richard J A M Stevens, Stevens R J A M Clercx H J H Lohse D   +4 more
core   +5 more sources

Efficient quantum thermal simulation

Nature
Abstract Quantum computers promise to tackle quantum simulation problems that are classically intractable 1 . Although a lot of quantum algorithms 2–4 have been developed for simulating quantum dynamics, a general-purpose method for ...
Chi-Fang Chen, Michael Kastoryano, Fernando G. S. L. Brandão, András Gilyén   +3 more
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Design and Optimization of the Inlet Header Structure in Microchannel Heat Exchanger Based on Flow Distribution Uniformity

Applied Sciences, 2022
The flow distribution in a printed circuit heat exchanger (PCHE) is of great theoretical and practical significance in the Brayton cycle power generation system.
Kaidi Zhang, Wei Wei, Yuwei Sun, Qiang Wu, Min Tang, Mingjian Lu   +5 more
doaj   +1 more source