Results 81 to 90 of about 1,369,127 (302)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Dual function additives: A small molecule crosslinker for enhanced efficiency and stability in organic solar cells [PDF]

, 2015
A bis‐azide‐based small molecule cross­linker is synthesized and evaluated as both a stabilizing and efficiency‐boosting additive in bulk heterojunction organic photovoltaic cells.
Ashraf, RS, Chabinyc, ML, Eisenmenger, ND, Huang, Z, Mcculloch, I, Meager, I, Nielsen, CB, Rumer, JW, Schroeder, BC   +8 more
core   +2 more sources

IMPROVING THERMAL EFFICIENCY OF PHOTOVOLTAIC THERMAL SYSTEMS

AURUM Journal of Engineering Systems and Architecture
The research presents the daily and monthly global solar radiation on a horizontal surface in Iraq and applies it to the PVT water system. The research contributes in two ways: first, it models a novel copper pipe system that improves thermal efficiency in an actual environment, and second, it investigates the hourly and daily intensity of solar ...
Mohammed Abbas Fadhil Alkhafaji, İbrahim Koç   +1 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Research on the cavitation characteristics and disinfection performance optimization of a rotor-radial groove hydrodynamic cavitation reactor

Results in Engineering
Rotary hydrodynamic cavitation reactor is widely used in the field of water treatment because of its excellent cavitation performance. A new type of arc rotor is presented in this paper.
Lei Wang, Sitong Guan, Chi Zhang, Yongxing Song, Yi Ge, Linhua Zhang, Jingting Liu, Weibin Zhang   +7 more
doaj   +1 more source

On the Efficiency of Thermal Conduction in Galaxy Clusters

, 2018
Galaxy clusters host a large reservoir of diffuse plasma with radially-varying temperature profiles. The efficiency of thermal conduction in the intracluster medium (ICM) is complicated by the existence of turbulence and magnetic fields, and has received
Fang, Xiang-Er, Guo, Fulai, Mou, Guobin, Yuan, Ye-Fei   +3 more
core   +1 more source

Nexus of thermal resilience and energy efficiency in buildings: A case study of a nursing home [PDF]

, 2020
Extreme weather events become more frequent and severe due to climate change. Although energy efficiency technologies can influence thermal resilience of buildings, they are traditionally studied separately, and their interconnections are rarely ...
Hong, T, Specian, M, Sun, K
core  

Acceleration Rates and Injection Efficiencies in Oblique Shocks [PDF]

, 1995
The rate at which particles are accelerated by the first-order Fermi mechanism in shocks depends on the angle, \teq{\Tbone}, that the upstream magnetic field makes with the shock normal.
Baring, M. G., Ellison, D. C., Jones, F. C.   +2 more
core   +2 more sources

Ingredients for an efficient thermal diode [PDF]

EPL (Europhysics Letters), 2015
We provide convincing empirical evidence that long range interactions strongly enhance the rectification effect which takes place in mass graded systems. Even more importantly the rectification does not decrease with the increase of the system size. Large rectification is obtained also for the equal mass case and with graded on-site potential.
Chen, Shunda, Pereira, Emmanuel, Casati, Giulio   +2 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source