Results 71 to 80 of about 486,842 (269)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Improvement of a Nusselt-Based Simulation Model for Heat Transfer in Rotary Heat Exchangers

open access: yesEnergies, 2020
In the last 50 years, the technology of rotary heat exchangers has not changed considerably. A reliable simulation can help improve the design of this technology.
Eloy Melian   +2 more
doaj   +1 more source

Estimating the Impact of Restructuring on Electricity Generation Efficiency: The Case of the Indian Thermal Power Sector [PDF]

open access: yes
We examine the impact of electricity sector restructuring on the operating efficiency of coal-fired power plants in India. Between 1995 and 2009, 85 percent of coal-based generation capacity owned by state governments was unbundled from vertically ...
Kabir Malik   +3 more
core  

Losses, Efficiency and Thermal Behavior of the Synchronous Motors with Different PM Materials

open access: yes, 2013
The paper deals with losses, efficiency and thermal behavior of the synchronous machines with different permanent magnet (PM) materials. Three PMSM are presented in this paper: First, the PMSM with NdFeB PM, which is really constructed. Second, the NdFeB
Lukas Kalamen   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Development of low cost thermal insulating materials

open access: yes, 2005
Includes bibliographical references.The disadvantaged people in South Africa are unfortunate by virtue of their financial status. It was estimated in 1992 that 20 % of the South African population live in informal settlements.
Meletse, Thabo Frans
core  

Thermal cooling using low-temperature waste heat: A cost-effective way for industrial companies to improve energy efficiency?

open access: yes, 2022
S.547-569As a typical cross-cutting technology, cooling and refrigeration equipment is used for a variety of industrial applications. While cooling is often provided by electric compression cooling systems, thermal cooling systems powered by low ...
Schall, D., Hirzel, S.
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

EFFECT OF THE FILL VENTILATION WINDOW ON PERFORMANCE OF A NATURAL DRAFT COOLING TOWER SUBJECTED TO CROSS-WINDS

open access: yesИзвестия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2016
Various aerodynamic design elements and technics (wind deflectors, wind walls, etc.) are utilized for improvement of the thermal efficiency of the natural draft cooling towers, particularly in conditions of cross wind.
K. V. Dobrego
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

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