Results 31 to 40 of about 1,078,541 (245)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A mask-based approach for the geometric calibration of thermal-infrared cameras [PDF]
, 2012 Accurate and efficient thermal-infrared (IR) camera calibration is important for advancing computer vision research within the thermal modality. This paper presents an approach for geometrically calibrating individual and multiple cameras in both the ...
Denman, Simon +5 more
core +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A Bayesian Estimator for Linear Calibration Error Effects in Thermal Remote Sensing
, 2005 The Bayesian Land Surface Temperature estimator previously developed has been extended to include the effects of imperfectly known gain and offset calibration errors. It is possible to treat both gain and offset as nuisance parameters and, by integrating
Morgan, J. A.
core +1 more source
Variational assimilation for xenon dynamical forecasts in neutronic using advanced background error covariance matrix modelling [PDF]
, 2013 Data assimilation method consists in combining all available pieces of information about a system to obtain optimal estimates of initial states.
Argaud, Jean-Philippe +5 more
core +4 more sources
EFFECTS OF COOLING SYSTEMS ON THE THERMAL BEHAVIOUR OF MACHINE TOOLS AND THERMAL ERROR MODELS
Journal of Machine Engineering, 2020 Today, cooling systems are increasingly applied to the structure of machine tools (MT). Unfortunately, to date there have been few efforts to precisely control these cooling systems, which inhibits the full utilisation of their potential to improve MT thermal behaviour (to reduce thermal errors). Moreover, the effects of cooling systems, especially the
Otakar Horejš +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Eigenstate thermalization hypothesis and approximate quantum error correction [PDF]
Journal of High Energy Physics, 2019 Abstract The eigenstate thermalization hypothesis (ETH) is a powerful conjecture for understanding how statistical mechanics emerges in a large class of many-body quantum systems. It has also been interpreted in a CFT context, and, in particular, holographic CFTs are expected to satisfy ETH.
Bao, Ning, Cheng, Newton
openaire +4 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source