Results 41 to 50 of about 258,969 (302)

A novel approach for ANFIS modelling based on Grey system theory for thermal error compensation

, 2014
The fast and accurate modelling of thermal errors in machining is an important aspect for the implementation of thermal error compensation. This paper presents a novel modelling approach for thermal error compensation on CNC machine tools.
Longstaff, Andrew P., Fletcher, Simon, Longstaff, Andrew P, Andrew P Longstaff, Ali M Abdulshahed, Abdulshahed, Ali, Simon Fletcher, Abdulshahed, Ali M.   +7 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Thermal Analysis for Condition Monitoring of Machine Tool Spindles

, 2012
Decreasing tolerances on parts manufactured, or inspected, on machine tools increases the requirement to have a greater understanding of machine tool capabilities, error sources and factors affecting asset availability. Continuous usage of a machine tool
Willoughby, P., Longstaff, Andrew P., Longstaff, A. P., Fletcher, Simon, Willoughby, Peter, Clough, D., Fletcher, S., Clough, David A   +7 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Research on Thermal Error Modeling of Motorized Spindle Based on BP Neural Network Optimized by Beetle Antennae Search Algorithm

Machines, 2021
High-speed motorized spindle heating will produce thermal error, which is an important factor affecting the machining accuracy of machine tools. The thermal error model of high-speed motorized spindles can compensate for thermal error and improve ...
Zhaolong Li, Bo Zhu, Ye Dai, Wenming Zhu, Qinghai Wang, Baodong Wang   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

A Novel Hybrid Neural Network with Optimized Feature Selection for Spindle Thermal Error Prediction

Applied System Innovation
In modern intelligent manufacturing, spindle thermal errors are critical to machining accuracy. To address this, we propose a two-stage prediction framework.
Lifeng Yin, Chenglong Li, Yaohan Peng, Hao Tang, Ningruo Wang, Huayue Chen   +5 more
doaj   +1 more source

Thermal error modelling for linear motor feed drive system considering multi-field coupling of electromagnetic-thermal-flow

Case Studies in Thermal Engineering, 2023
Thermal error is a crucial factor affecting the accuracy of linear motor feed drive systems (LMFDS). To improve the prediction accuracy, a thermal error model for LMFDS considering the multi-field coupling of electromagnetic-thermal-flow (EM-TF) is ...
Maolei Chen, Sitong Xiang, Jianguo Yang
doaj   +1 more source