Results 41 to 50 of about 1,078,541 (245)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Potential sources of error during virus thermal inactivation [PDF]

Applied and Environmental Microbiology, 1978
A review of virus thermal inactivation data published in the literature demonstrated variations in reported virus resistance. Examination of the methods used indicated that numerous studies were made by heat processing virus suspensions in test tubes.
J T, Tierney, E P, Larkin
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Overview of Advanced LIGO Adaptive Optics

, 2016
This is an overview of the adaptive optics used in Advanced LIGO (aLIGO), known as the thermal compensation system (TCS). The thermal compensation system was designed to minimize thermally-induced spatial distortions in the interferometer optical modes ...
Abbott, Benjamin, Arain, Muzammil A., Brooks, Aidan F., Ciani, Giacomo, Cole, Ayodele, Grabeel, Greg, Guido, Chris, Gustafson, Eric, Heintze, Matthew, Heptonstall, Alastair, Jacobson, Mindy, Kim, Won, King, Eleanor, Lynch, Alexander, Mailand, Ken, Mueller, Guido, Munch, Jesper, O'Connor, Stephen, Ottaway, David, Sannibale, Virginio, Shao, Zhenhua, Smith, Michael, Veitch, Peter, Vo, Thomas, Vorvick, Cheryl, Willems, Phil   +25 more
core   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Thermal blinding of gated detectors in quantum cryptography

, 2010
It has previously been shown that the gated detectors of two commercially available quantum key distribution (QKD) systems are blindable and controllable by an eavesdropper using continuous-wave illumination and short bright trigger pulses, manipulating ...
Bethune, Braunstein, Carlos Wiechers, Chau, Christoffer Wittmann, Cova, Cova, Dominique Elser, Ekert, Fung, Fung, Gisin, Gisin, Gottesman, Gottesman, Hwang, Inamori, Johannes Skaar, Lamas-Linares, Lars Lydersen, Lo, Lo, Lydersen, Lydersen, Makarov, Makarov, Makarov, Makarov, Makarov, Marcikic, Marøy, Nauerth, Peloso, Qi, Ribordy, Ribordy, Scarani, Shor, Stucki, Stucki, Tomita, Vadim Makarov, Vakhitov, Wang, Xu, Yuan, Yuan, Zhao   +47 more
core   +1 more source

Estimation of Systematic Errors of MODIS Thermal Infrared Bands [PDF]

IEEE Geoscience and Remote Sensing Letters, 2006
This letter reports a statistical method to estimate detector-dependent systematic error in Moderate Resolution Imaging Spectroradiometer (MODIS) thermal infrared (TIR) Bands 20-25 and 27-36. There exist scan-to-scan overlapped pixels in MODIS data. By analyzing a sufficiently large amount of those most overlapped pixels, the systematic error of each ...
Liang, Shunlin, Liu, Ronggao G., Liu, Jiyuan Y.   +2 more
openaire   +1 more source

Thermoreflectance Detection of Point Defects Resulting from Focused Ion Beam Milling

Advanced Engineering Materials, EarlyView.
Focused ion beam (FIB) milling is a common tool for nanoscale material processing, however irradiation damage, redeposition, and contamination can occur. We use several characterization tools to show FIB‐induced effects beyond 1 mm from the milled area.
Thomas W. Pfeifer, Eric R. Hoglund, Anton V. Ievlev, Patrick E. Hopkins   +3 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source