Results 91 to 100 of about 1,078,179 (287)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

How Phase Transitions Impact Changes in Mantle Convection Style Throughout Earth's History: From Stalled Plumes to Surface Dynamics

Geochemistry, Geophysics, Geosystems
Mineral phase transitions can either hinder or accelerate mantle flow. In the present day, the formation of the bridgmanite + ferropericlase assemblage from ringwoodite at 660 km depth has been found to cause weak and intermittent layering of mantle ...
Ranpeng Li, Juliane Dannberg, Rene Gassmöller, Carolina Lithgow‐Bertelloni, Lars Stixrude   +4 more
doaj   +1 more source

Mechanisms behind thermal evolution of the structural alignment of polycyclic aromatic hydrocarbons in coals: Implications for structural transition of coal macromolecules

Meitian dizhi yu kantan
ObjectiveCoals are highly sensitive to variations in temperature and pressure conditions. The structural evolution of coal macromolecules, driven by tectono-thermal processes, is the key to understanding coal rank transition and geological evolution. The
Yu SONG, Bo JIANG, Guoxi CHENG, Sijian ZHENG, Ming LI, Yao GE, Yan DAI, Qian WANG, Guangjun FENG   +8 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Assessing the Accuracy of 2‐D Planetary Evolution Models Against the 3‐D Sphere

Geochemistry, Geophysics, Geosystems
Regardless of the steady increase of computing power during the last decades, numerical models in a 3D spherical shell are only used in specific setups to investigate the thermochemical convection in planetary interiors, while 2D geometries are typically
A. Fleury, A.‐C. Plesa, C. Hüttig, D. Breuer   +3 more
doaj   +1 more source

The Tale of the Residual Tail: Insights From Continuous Intracranial Monitoring From Post‐Hippocampectomy Dynamics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Subtotal hippocampal resection can leave residual hippocampal tissue, yet the immediate postoperative electrophysiologic evolution of such remnants is unknown. We describe a patient with drug‐resistant temporal lobe epilepsy in whom a hippocampal remnant was continuously monitored using a responsive neurostimulator (RNS) following subtotal ...
Patrick Hartnett, Syeda Amrah Hashmi, Amaan Qureshi, Heather Spader, Shayan Moosa, Ifrah Zawar   +5 more
wiley   +1 more source

Radiogenic Heating as the Thermal Driver of Himalayan Crustal Heating During Prolonged Thickening

Geochemistry, Geophysics, Geosystems
The thermal evolution of the crust during continental collision evolves from cold to hot with time, which impacts crustal reworking and differentiation.
Shuaiqi Liu, Guibin Zhang, Lifei Zhang, Shuzhen Wang, Feng Chang   +4 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source