Results 81 to 90 of about 4,483,704 (311)

Thermal shielding of an emerging active region [PDF]

open access: yes, 2012
Context. The interaction between emerging active regions and the pre-existing coronal magnetic field is important for better understanding the mechanisms of storage and release of magnetic energy from the convection zone to the high corona. Aims.
Regnier, Stephane, S. Régnier
core   +1 more source

Effect of Iron Content on the Thermal Conductivity and Thermal Diffusivity of Orthopyroxene

open access: yesGeochemistry, Geophysics, Geosystems
The thermal properties of major minerals play a key role in understanding the internal dynamic mechanism and thermal evolution of the Earth and rocky planets.
Xinzhuan Guo   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Temporal–Spatial Evolution of Kinetic and Thermal Energy Dissipation Rates in a Three-Dimensional Turbulent Rayleigh–Taylor Mixing Zone

open access: yesEntropy, 2020
In this work, the temporal–spatial evolution of kinetic and thermal energy dissipation rates in three-dimensional (3D) turbulent Rayleigh–Taylor (RT) mixing are investigated numerically by the lattice Boltzmann method. The temperature fields, kinetic and
Wenjing Guo   +3 more
doaj   +1 more source

Thermal evolution of the core with a high thermal conductivity [PDF]

open access: yesPhysics of the Earth and Planetary Interiors, 2015
Abstract The rate at which heat is extracted across the core mantle boundary (CMB) is constrained by the requirement of dynamo action in the core. This constraint can be computed explicitly using the entropy balance of the core and depends on the thermal conductivity, whose value has been revised upwardly. A high order model (fourth degree polynomial
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Adaptive evolution shapes the present-day distribution of the thermal sensitivity of population growth rate.

open access: yesPLoS Biology, 2020
Developing a thorough understanding of how ectotherm physiology adapts to different thermal environments is of crucial importance, especially in the face of global climate change.
Dimitrios-Georgios Kontopoulos   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Numerical analysis of coupled effects of pulsatile blood flow and thermal relaxation time during thermal therapy

open access: yes, 2012
The main purpose of this study is to investigate the coupled effects of the pulsatile blood flow in thermally significant blood vessels and the thermal relaxation time in living tissues on temperature distributions during thermal treatments.
Shih, Tzu-Ching; Horng, Tzyy-Leng   +1 more
core   +1 more source

Thermal Evolution of the Impact‐Induced Cryomagma Chamber Beneath Occator Crater on Ceres

open access: yesGeophysical Research Letters, 2019
The faculae in Occator Crater on dwarf planet Ceres are an accumulation of salts that have been interpreted as cryovolcanic products. Current age estimates from crater counting suggest a maximum 18‐Ma difference between the crater forming impact and the ...
M. A. Hesse, J. C. Castillo‐Rogez
doaj   +1 more source

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