Results 61 to 70 of about 1,078,179 (287)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Applied SciencesThe Helanshan Mountain tectonic belt (HTB) is an intraplate deformation belt along the northwestern border of the Ordos Block in the North China Craton.
Cheng Wu +3 more
doaj +1 more source
Thermal–orbital evolution of Eris
IcarusThe large Kuiper Belt object (KBO) Eris is nearly as big as Pluto and has a small moon, Dysnomia. Constraints on the system's spin and orbit characteristics were recently used to argue for a dissipative Eris, requiring a differentiated structure but not necessarily a subsurface ocean.
Ryunosuke Akiba, Francis Nimmo
openaire +2 more sources
Energy-Dependent Timing of Thermal Emission in Solar Flares
, 2011 We report solar flare plasma to be multi-thermal in nature based on the theoretical model and study of the energy-dependent timing of thermal emission in ten M-class flares.
A. Caspi +33 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
R\'enyi entropy of locally excited states with thermal and boundary effect in 2D CFTs
, 2015 We study R\'enyi entropy of locally excited states with considering the thermal and boundary effects respectively in two dimensional conformal field theories (CFTs).
Guo, Wu-Zhong, He, Song
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Thermal Evolution of the Impact‐Induced Cryomagma Chamber Beneath Occator Crater on Ceres
Geophysical Research Letters, 2019 The faculae in Occator Crater on dwarf planet Ceres are an accumulation of salts that have been interpreted as cryovolcanic products. Current age estimates from crater counting suggest a maximum 18‐Ma difference between the crater forming impact and the ...
M. A. Hesse, J. C. Castillo‐Rogez
doaj +1 more source