Results 71 to 80 of about 184,702 (266)

Residual stress evolution regularity in thermal barrier coatings under thermal shock loading

Theoretical and Applied Mechanics Letters, 2014
Residual stress evolution regularity in thermal barrier ceramic coatings (TBCs) under different cycles of thermal shock loading of 1100°C was investigated by the microscopic digital image correlation (DIC) and micro-Raman spectroscopy, respectively.
Ximin Chen, Zhanwei Liu, Yang Yang
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Mechanisms behind thermal evolution of the structural alignment of polycyclic aromatic hydrocarbons in coals: Implications for structural transition of coal macromolecules

Meitian dizhi yu kantan
ObjectiveCoals are highly sensitive to variations in temperature and pressure conditions. The structural evolution of coal macromolecules, driven by tectono-thermal processes, is the key to understanding coal rank transition and geological evolution. The
Yu SONG, Bo JIANG, Guoxi CHENG, Sijian ZHENG, Ming LI, Yao GE, Yan DAI, Qian WANG, Guangjun FENG   +8 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

How Phase Transitions Impact Changes in Mantle Convection Style Throughout Earth's History: From Stalled Plumes to Surface Dynamics

Geochemistry, Geophysics, Geosystems
Mineral phase transitions can either hinder or accelerate mantle flow. In the present day, the formation of the bridgmanite + ferropericlase assemblage from ringwoodite at 660 km depth has been found to cause weak and intermittent layering of mantle ...
Ranpeng Li, Juliane Dannberg, Rene Gassmöller, Carolina Lithgow‐Bertelloni, Lars Stixrude   +4 more
doaj   +1 more source

Thermal evolution characteristics and petroleum geological significance of Paleogene Yacheng Formation source rocks on northern slope of Lingshui Sag, Qiongdongnan Basin

Shiyou shiyan dizhi
The source rocks of the Paleogene Yacheng Formation in the Lingshui Sag of the Qiongdongnan Basin are the most important source rocks for the "Deep Sea No. 1" gas field.
Chunhua NI
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Assessing the Accuracy of 2‐D Planetary Evolution Models Against the 3‐D Sphere

Geochemistry, Geophysics, Geosystems
Regardless of the steady increase of computing power during the last decades, numerical models in a 3D spherical shell are only used in specific setups to investigate the thermochemical convection in planetary interiors, while 2D geometries are typically
A. Fleury, A.‐C. Plesa, C. Hüttig, D. Breuer   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Radiogenic Heating as the Thermal Driver of Himalayan Crustal Heating During Prolonged Thickening

Geochemistry, Geophysics, Geosystems
The thermal evolution of the crust during continental collision evolves from cold to hot with time, which impacts crustal reworking and differentiation.
Shuaiqi Liu, Guibin Zhang, Lifei Zhang, Shuzhen Wang, Feng Chang   +4 more
doaj   +1 more source